Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
fosfomycin resistance hydrolase FosX
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| FosX | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 18 | Fosfomycin | Listeria monocytogenes EGD-e, Solidesulfovibrio magneticus RS-1, Listeria monocytogenes, Mycobacteroides abscessus subsp. bolletii F1725, Pseudomonas aeruginosa, Clostridium botulinum, Brucella melitensis, Listeria innocua, Enterococcus faecium, L. monocytogenes | Uruguay, China, Europe, Spain, Portugal, Italy, Morocco, Poland, Sicily, Western Cape, South Africa +1 more | 2007, 2009, 2017, 2018, 2020, 2022, 2024, 2025 | AL591981.1 | CAC99780.1 |
| FosH | Card DatabaseReference Gene CatalogResFinder Database | 4 | Fosfomycin, Phosphonic acid antibiotic | Pseudomonas aeruginosa | - | - | DQ342344.1 | ABD22979.1 |
Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes.
Research Article
Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes.
Research Article
Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria., Comparative genomics of Listeria species.
Research Article
Fosfomycin: Mechanism and Resistance.
Review
The paper discusses the mechanisms of fosfomycin resistance, including the identification of fosfomycin-modifying enzymes such as FosA, FosB, FosX, and FosA3, which inactivate fosfomycin and contribute to resistance in various bacterial species.
Epistatic control of intrinsic resistance by virulence genes in Listeria.
Research Article
The fosX gene confers intrinsic fosfomycin resistance in Listeria species, but this resistance is epistatically suppressed by the PrfA virulence regulon, making Listeria monocytogenes susceptible to fosfomycin during infection.
Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing.
Research Article
The study compared hybrid assembly approaches for bacterial pathogen genomes and identified AMR genes such as blaZ, msr(A), and tet(K) in Staphylococcus aureus.
Does Shiga Toxin-Producing Escherichia coli and Listeria monocytogenes Contribute Significantly to the Burden of Antimicrobial Resistance in Uruguay?
Research Article
The study identified several antimicrobial resistance genes in Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes isolates, including aph(3")-Ib, aph(3′)-Ia, aph(6)-Id, blaTEM-1B, sul2, tet(A), fosX, lin, norB, lde, mdrL, and fepA. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, fosfomycin, lincomycin, ciprofloxacin, and erythromycin.
High Prevalence and Overexpression of Fosfomycin-Resistant Gene fosX in Enterococcus faecium From China.
Research Article
The study identified fosX as a major fosfomycin resistance gene in Enterococcus faecium, showing that its overexpression increases resistance levels significantly.
Application of MinION sequencing as a tool for the rapid detection and characterization of Listeria monocytogenes in smoked salmon.
Research Article
The study identified five antimicrobial resistance genes (norB, msrA, mprF, mepA, and FosX) in Listeria monocytogenes strains using MinION sequencing and the CARD database.
Prevalence and Population Diversity of Listeria monocytogenes Isolated from Dairy Cattle Farms in the Cantabria Region of Spain.
Research Article
The study identified four antimicrobial resistance genes (fosX, lin, norB, and mprF) in 45 L. monocytogenes isolates, with resistance to various antibiotics including fosfomycin, lincomycin, quinolones, and cationic peptides. No significant differences in resistance ratios were found between organic and conventional farms.
Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.
Research Article
The study identified various AMR genes in L. monocytogenes, Salmonella enterica, and S. aureus isolates from artisanal food production chains in the Mediterranean region, highlighting the presence of fosfomycin, aminoglycoside, beta-lactam, trimethoprim, sulfonamide, tetracycline, and streptomycin resistance mechanisms.
High-Pressure Processing Influences Antibiotic Resistance Gene Transfer in Listeria monocytogenes Isolated from Food and Processing Environments.
Research Article
The study found that high-pressure processing (HPP) at 400 MPa increased the transfer frequency of fosX, tet_A1, tet_A3, and tetC genes in Listeria monocytogenes, which confer resistance to fosfomycin and tetracycline. The Lde gene, which confers ciprofloxacin resistance, was not transferred under any conditions.
Molecular Characterization and Antimicrobial Resistance Evaluation of Listeria monocytogenes Strains from Food and Human Samples.
Research Article
The study identified several intrinsic antimicrobial resistance genes in Listeria monocytogenes strains, including fosX, norB, sul, and lmo0919, which confer resistance to fosfomycin, quinolones, sulfonamides, and lincosamides, respectively.
Profiling Listeria monocytogenes in Hummus, Fresh Produce, and Food Processing Environments in the Western Cape, South Africa.
Research Article
The study identified the tetM gene conferring resistance to tetracycline, doxycycline, and minocycline in two lineage I, serotype 1/2b, ST5 isolates from RTE hummus. All 20 isolates were found to contain the fosX gene, which encodes resistance to fosfomycin.
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