frdD

fumarate reductase subunit D

Validation StatusCandidate

Overview

Mechanism: confers resistance to beta-lactams via modification of the overlapping promoter of ampC
Validation Method: experimental validation in E. coli BW25113
Drug Classes: Ampicillin, Amoxicillin
Organisms: Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	G4T	-	Escherichia coli	Amoxicillin	Reslit	Candidate

Papers2

Global pathogenomic analysis identifies known and candidate genetic antimicrobial resistance determinants in twelve species.

PMID 38001096 · 2023

Two candidate AMR genes, cycA and frdD, were experimentally validated in E. coli BW25113, showing conditional resistance to ciprofloxacin and ampicillin, respectively.

Gene Information

Gene Name: frdD
Allele: frdD
Encodes: fumarate reductase subunit D
Source Database: Reslit
Mechanism: confers resistance to beta-lactams via modification of the overlapping promoter of ampC
Confers Resistance To: Ampicillin
Organisms Tested In: • Escherichia coli
Validation Method: experimental validation in E. coli BW25113

Browse AMR Genes

frdD

Mutations

Gene Information