fruB

Fructose 1-phosphate kinase

Validation StatusCandidate

Overview

Mechanism: mutation
Validation Method: whole-genome sequencing and growth curve analysis
Drug Classes: Oxacillin, Oxacillin|Cefoxitin|Imipenem, NIT|GEN
Organisms: Staphylococcus aureus, Escherichia coli
Geographic Location: United States
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A211E	-	loss-of-function	Staphylococcus aureus	Oxacillin\|Cefoxitin\|ImipenemOxacillin	Reslit	Candidate
-	T5457C	-	Escherichia coli	NIT\|GEN	Reslit	Candidate

Papers3

Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus.

PMID 29555636 · 2018

The study identified six genes (fruB, gmk, hpt, purB, prsA, and relA) that are mutated in highly oxacillin-resistant strains of MRSA, highlighting the role of guanine metabolism in determining antibiotic resistance.

Gene Information

Gene Name: fruB
Allele: fruB
Encodes: Fructose 1-phosphate kinase
Source Database: Reslit
Mechanism: mutation
Confers Resistance To: Oxacillin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: United States
Validation Method: whole-genome sequencing and growth curve analysis
Sequence Accession: PRJEB24730

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fruB

Mutations

Gene Information