Browse AMR Genes

ftsI: p.D350N ftsI: p.S357N ftsI: p.M377I ftsI: p.S385T ftsI: p.L389F ftsI: p.R517H ftsI: p.N526K

Protein Change: R504C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: meropenem
Validation Method: genomic analysis, MIC measurement
Source Database: Reslit

Molecular and Drug Resistance Characteristics of Haemophilus influenzae Carried by Pediatric Patients with Adenoid Hypertrophy.

Research Article

PMID 40871268 · 2025

Mutations in ftsI gene encoding PBP3 are associated with beta-lactam resistance in H. influenzae.

Mutation Information

Protein Change: D350N, S357N, M377I, S385T, L389F, R517H, N526K
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillinamoxicillin clavulanic acid
Validation Method: sequencing and antibiotic susceptibility testing
Source Database: Reslit

Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.

Research Article

PMID 15105114 · 2004

Mutations in ftsI contribute to high-level ampicillin resistance in BLNAR strains.

Mutation Information

ftsI: p.R517H ftsI: p.N526K

Protein Change: R517H, N526K
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillin
Validation Method: sequencing and transformation experiments
Source Database: Reslit

Beta-lactam effects on mixed cultures of common respiratory isolates as an approach to treatment effects on nasopharyngeal bacterial population dynamics.

Research Article

PMID 19052648 · 2008

mutation in the ftsI gene

Mutation Information

ftsI: p.Q227H ftsI: p.E353K ftsI: p.I536L ftsI: p.A417V ftsI: p.L139R ftsI: p.N366Y

Protein Change: N526K
Organisms: Haemophilus influenzae, Streptococcus pyogenes, Streptococcus pneumoniae
Confers Resistance To: ampicillin
Validation Method: determined by PCR amplification and direct sequencing
Source Database: Reslit

Emergence of high-level aztreonam-avibactam and cefiderocol resistance following treatment of an NDM-producing Escherichia coli bloodstream isolate exhibiting reduced susceptibility to both agents at baseline.

Research Article

PMID 39239090 · 2024

mutations in ftsI are associated with reduced susceptibility to ATM–AVI and FDC

Mutation Information

Protein Change: Q227H, E353K, I536L, A417V, L139R, N366Y
Organisms: Escherichia coli
Confers Resistance To: aztreonamceftazidime avibactamcefiderocol
Validation Method: whole-genome sequencing and susceptibility testing
Source Database: Reslit

Mutations leading to ceftolozane/tazobactam and imipenem/cilastatin/relebactam resistance during in vivo exposure to ceftazidime/avibactam in Pseudomonas aeruginosa.

Research Article

PMID 39932323 · 2025

Mutation Information

ftsI: p.N526K ftsI: p.S385T ftsI: p.L389F ftsI: p.R517H

Protein Change: R504C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftolozane tazobactamimipenem relebactamceftazidime avibactam
Validation Method: whole-genome sequencing and MIC testing
Source Database: Reslit

Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae.

Research Article

PMID 40980920 · 2025

Mutations in ftsI are associated with increased MICs for beta-lactam antibiotics.

Mutation Information

ftsI: p.T322I

Protein Change: T322I
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillincefotaximeceftriaxone
Validation Method: clone analysis and MIC testing
Source Database: Reslit

Rapid acquisition of daptomycin resistance in a Corynebacterium striatum osteoarticular infection: case report and discussion on antimicrobial resistance.

Research Article

PMID 41244273 · 2025

The A370D substitution affects cell division and peptidoglycan synthesis.

Mutation Information

ftsI: p.A370D

Protein Change: A370D
Organisms: Corynebacterium striatum
Confers Resistance To: beta lactams
Validation Method: whole genome sequencing
Source Database: Reslit

Genetic approach to study the relationship between penicillin-binding protein 3 mutations and Haemophilus influenzae beta-lactam resistance by using site-directed mutagenesis and gene recombinants.

Research Article

PMID 15980357 · 2005

Mutation Information

Protein Change: N526K, S385T, L389F, R517H
Organisms: Haemophilus influenzae
Confers Resistance To: cefoxitincefotaximecefdinircefprozilceftriaxoneampicillinimipenemmeropenem
Validation Method: site-directed mutagenesis and susceptibility testing
Source Database: Reslit

High potency of sequential therapy with only β-lactam antibiotics.

Research Article

PMID 34318749 · 2021

Mutation Information

ftsI: p.V471G

Protein Change: V471G
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbenicillincefuroximedoripenem
Validation Method: Whole-genome sequencing and resistance profiling; whole-genome sequencing and phenotypic analysis
Source Database: Reslit

Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection.

Research Article

PMID 34826267 · 2021

Mutation Information

ftsI: p.G63C

Protein Change: G63C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: meropenem
Validation Method: experimental validation; genome analysis
Source Database: Reslit

Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae.

Review

PMID 39633433 · 2024

Mutations in ftsI confer resistance to ampicillin and cefotaxime.

Mutation Information

ftsI: p.M377I ftsI: p.A502V ftsI: p.N526K ftsI: p.V547I ftsI: p.N569S

Protein Change: M377I, A502V, N526K, V547I, N569S
Confers Resistance To: ampicillincefotaxime
Validation Method: genome-wide association study; genotype-phenotype association
Source Database: Reslit

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa.

Research Article

PMID 40621918 · 2025

Mutations in the PB domain of ftsI reduce carbapenem susceptibility while increasing susceptibility to cefiderocol and piperacillin.

Mutation Information

ftsI: p.L89V ftsI: p.M460T ftsI: p.V471G ftsI: p.R504C ftsI: p.P527S ftsI: p.F533L ftsI: p.V537L ftsI: p.P527T

Protein Change: L89V, M460T, V471G, R504C, P527S, F533L, V537L, P527T
Confers Resistance To: carbapenemscephalosporins
Validation Method: broth microdilution and growth parameter analysis; Antimicrobial susceptibility testing and molecular modeling
Source Database: Reslit

Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics.

Research Article

PMID 40724005 · 2025

Mutation Information

ftsI: p.E349K

Protein Change: E349K
Organisms: Escherichia coli
Confers Resistance To: cefiderocol
Validation Method: identification in resistant isolates
Source Database: Reslit

The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.

Research Article

PMID 40763289 · 2025

Mutation Information

Protein Change: F533L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftolozane tazobactam
Validation Method: WGS analysis
Source Database: Reslit

Outbreak of a beta-lactam resistant non-typeable Haemophilus influenzae sequence type 14 associated with severe clinical outcomes.

Research Article

PMID 26700635 · 2015

The mutation in the ftsI gene encoding penicillin-binding protein (PBP) 3 was associated with high MIC-values of ampicillin, cefuroxime and cefotaxime.

Mutation Information

Protein Change: N526K
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillincefuroximecefotaxime
Validation Method: MIC testing
Source Database: Reslit

Activity of Imipenem-Relebactam against a Large Collection of Pseudomonas aeruginosa Clinical Isolates and Isogenic β-Lactam-Resistant Mutants.

Research Article

PMID 31740559 · 2020

ftsI mutation contributes to resistance against ceftolozane-tazobactam and ceftazidime-avibactam.

Mutation Information

ftsI: p.S385T ftsI: p.L389F ftsI: p.N526K ftsI: p.R517H ftsI: p.Y557H

Protein Change: F533L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftolozane tazobactamceftazidime avibactam
Validation Method: susceptibility testing
Source Database: Reslit

Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae.

Research Article

PMID 31996416 · 2020

Mutations in the transpeptidase region of ftsI contribute to resistance against extended-spectrum cephalosporins.

Mutation Information

Protein Change: S385T, L389F, N526K, R517H, Y557H
Confers Resistance To: cefoxitincefotaximecefpodoximeceftriaxone
Validation Method: whole-genome sequencing
Source Database: Reslit

Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA).

Research Article

PMID 38559355 · 2024

Mutation Information

ftsI: p.Y103D

Protein Change: Y103D
Organisms: Haemophilus parasuis, E. coli
Confers Resistance To: cefaclor
Validation Method: cloning in E. coli DH5α and determination of MIC
Source Database: Reslit

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children.

Research Article

PMID 38651222 · 2024

mutations in ftsI gene associated with ceftriaxone resistance

Mutation Information

ftsI: p.N526K ftsI: p.R517H ftsI: p.S385T ftsI: p.L389F

Protein Change: N526K, R517H, S385T, L389F
Organisms: Haemophilus influenzae
Confers Resistance To: ceftriaxone
Validation Method: sequencing
Source Database: Reslit

Characteristics of Haemophilus influenzae invasive isolates from Portugal following routine childhood vaccination against H. influenzae serotype b (2002-2010).

Research Article

PMID 24154654 · 2014

Mutations in the ftsI gene were associated with reduced susceptibility to ampicillin.

Mutation Information

Protein Change: N526K
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillin
Validation Method: sequencing of the ftsI gene
Source Database: Reslit

Molecular epidemiology of nontypeable Haemophilus influenzae causing community-acquired pneumonia in adults.

Research Article

PMID 24349303 · 2013

Mutations in ftsI gene lead to beta-lactam resistance

Mutation Information

ftsI: p.D350N ftsI: p.S357N ftsI: p.M377I ftsI: p.S385T ftsI: p.L389F ftsI: p.N526H

Protein Change: N526K
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillin
Validation Method: sequencing
Source Database: Reslit

High Prevalence of Group III-Like Mutations Among BLPACR and First Report of Haemophilus influenzae ST95 Isolated from Blood in China.

Research Article

PMID 36824068 · 2023

Mutations in ftsI were associated with beta-lactam resistance

Mutation Information

Protein Change: D350N, S357N, M377I, S385T, L389F, N526H
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillinamoxicillin clavulanic acid
Validation Method: sequencing
Source Database: Reslit

Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals.

Research Article

PMID 36877058 · 2023

Mutation Information

ftsI: p.N117S

Protein Change: N117S
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftazidime avibactam
Validation Method: WGS
Source Database: Reslit

Haemophilus influenzae carriage and antibiotic resistance profile in Belgian infants over a three-year period (2016-2018).

Research Article

PMID 37168112 · 2023

Mutations in the ftsI gene were found in 81.0% of the strains.

Mutation Information

ftsI: p.H517R ftsI: p.K526N

Protein Change: H517R, K526N
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillinamoxicillin clavulanic acid
Validation Method: sequencing of the ftsI gene
Source Database: Reslit

Molecular characterization of multidrug-resistant non-typeable Haemophilus influenzae with high-level resistance to cefuroxime, levofloxacin, and trimethoprim-sulfamethoxazole.

Research Article

PMID 37407940 · 2023

Mutation Information

ftsI: p.S357N ftsI: p.T532S ftsI: p.Y557H

Protein Change: S357N, T532S, Y557H
Organisms: non-typeable Haemophilus
Confers Resistance To: cefuroxime
Validation Method: genomic variation analysis
Source Database: Reslit

Evolution of extended-spectrum β-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.

Research Article

PMID 38168243 · 2023

Mutation Information

ftsI: p.A413V ftsI: p.A413T

Protein Change: A413V, A413T
Confers Resistance To: cefoxitincefotaximecefpodoximeceftriaxonecephalexinphenicolsciprofloxacinerythromycinlevofloxacinlinezolidnitrofurantoinpenicillintetracyclinetrimethoprim
Source Database: Reslit

Imipenem heteroresistance but not tolerance in Haemophilus influenzae during chronic lung infection associated with chronic obstructive pulmonary disease.

Research Article

PMID 38179447 · 2023

mutations in ftsI gene associated with imipenem heteroresistance

Mutation Information

ftsI: p.A62S ftsI: p.L124I ftsI: p.K127T ftsI: p.M377I ftsI: p.N526L ftsI: p.A530S

Protein Change: A62S, L124I, K127T, M377I, N526L, A530S
Confers Resistance To: imipenem
Validation Method: allelic variation analysis
Source Database: Reslit

Microbiological characterization of Streptococcus pneumoniae and non-typeable Haemophilus influenzae isolates as primary causes of acute otitis media in Bulgarian children before the introduction of conjugate vaccines.

Research Article

PMID 23531034 · 2013

Mutation Information

ftsI: p.R517H ftsI: p.N526K ftsI: p.D350N ftsI: p.G490E ftsI: p.A530S ftsI: p.M377I ftsI: p.A502V ftsI: p.A502T

Protein Change: R517H, N526K, D350N, G490E, A530S, M377I, A502V, A502T
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillin
Validation Method: DNA sequencing
Source Database: Reslit

Genome analysis of a transmissible lineage of pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators.

Research Article

PMID 24039595 · 2013

Mutation Information

ftsI: p.N789S

Protein Change: N789S
Organisms: Pseudomonas aeruginosa
Confers Resistance To: penicillin
Validation Method: mutation detected via genomic analysis
Source Database: Reslit

Ampicillin-resistant Haemophilus influenzae isolates in Geneva: serotype, antimicrobial susceptibility, and β-lactam resistance mechanisms.

Research Article

PMID 26187432 · 2015

Mutations in the ftsI gene are associated with ampicillin resistance in Haemophilus influenzae.

Mutation Information

ftsI: p.N526K ftsI: p.V547I ftsI: p.D569S ftsI: p.A502V ftsI: p.D350N ftsI: p.M377I ftsI: p.I449V ftsI: p.R517H

Protein Change: N526K, V547I, D569S, A502V, D350N, M377I, I449V, R517H
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillin
Validation Method: sequencing of the ftsI gene
Source Database: Reslit

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa.

Research Article

PMID 29089424 · 2017

Mutation Information

ftsI: p.R504H ftsI: p.V239A

Protein Change: R504H, V239A
Organisms: Pseudomonas aeruginosa
Confers Resistance To: aztreonam
Validation Method: whole-genome sequencing
Source Database: Reslit

Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter cinaedi.

Research Article

PMID 29203490 · 2018

Mutation Information

ftsI: p.R351H ftsI: p.E419K

Protein Change: R351H, E419K
Organisms: Helicobacter cinaedi
Confers Resistance To: amoxicillin
Validation Method: transformation and penicillin binding assays
Source Database: Reslit

Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan.

Research Article

PMID 29352811 · 2018

Mutation Information

ftsI: p.D350N ftsI: p.S357N ftsI: p.M377I ftsI: p.S385T ftsI: p.L389F ftsI: p.V562L

Protein Change: D350N, S357N, M377I, S385T, L389F, V562L
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillin
Validation Method: SNP analysis and correlation with MICs
Source Database: Reslit

A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility.

Research Article

PMID 29855260 · 2018

The wild-type ftsI gene was susceptible to aminopenicillins.

Mutation Information

ftsI: p.Y528H

Protein Change: Y528H
Organisms: Haemophilus influenzae, Escherichia coli
Confers Resistance To: ampicillinamoxicillin
Validation Method: site-directed mutagenesis and broth microdilution
Source Database: Reslit

Polymorphism of ftsI gene in Haemophilus influenzae and emergence of cefotaxime resistance in two Tunisian hospitals.

Research Article

PMID 32489667 · 2020

The mutation N422I was observed in the Hi15 strain and is associated with increased resistance to cefotaxime.

Mutation Information

ftsI: p.N422I

Protein Change: N422I
Organisms: Haemophilus influenzae
Confers Resistance To: cefotaxime
Validation Method: PCR and sequencing
Source Database: Reslit

Evaluation of in vitro activity of ceftolozane/tazobactam and comparators against recent clinical bacterial isolates, and genomics of Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli isolates that demonstrated resistance to ceftolozane/tazobactam: data from Kuwait and Oman.

Research Article

PMID 35465239 · 2022

Mutations in ftsI were identified in E. coli isolates.

Mutation Information

ftsI: p.A539T ftsI: p.E149D ftsI: p.Q227H ftsI: p.T233A ftsI: p.V332I ftsI: p.A413V ftsI: p.E349K

Protein Change: A539T, E149D, Q227H, T233A, V332I, A413V, E349K
Confers Resistance To: ceftolozane tazobactam
Source Database: Reslit

Molecular epidemiology and antibiotic resistance profiles of invasive Haemophilus influenzae from Norway 2017-2021.

Research Article

PMID 36106084 · 2022

Mutations in ftsI (PBP3) contribute to reduced susceptibility to beta-lactams.

Mutation Information

ftsI: p.D350N ftsI: p.M377I ftsI: p.A502V ftsI: p.N526K ftsI: p.V547I ftsI: p.N569S

Protein Change: D350N, M377I, A502V, N526K, V547I, N569S
Confers Resistance To: ampicillincefuroxime
Validation Method: whole-genome sequencing and correlation with phenotypic resistance
Source Database: Reslit

Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.

Research Article

PMID 38849863 · 2024

missense mutation

Mutation Information

ftsI: p.G63D

Protein Change: G63D
Organisms: Pseudomonas aeruginosa
Confers Resistance To: imipenemceftazidimecefepimepiperacillintazobactampiperacillin tazobactam
Source Database: Reslit

Penicillin-binding protein 3 sequence variations reduce susceptibility of Pseudomonas aeruginosa to β-lactams but inhibit cell division.

Research Article

PMID 39001778 · 2024

All mutations are in the catalytic domain of PBP3 and reduce susceptibility to various β-lactams.

Mutation Information

ftsI: p.V471G ftsI: p.R504C ftsI: p.F533L ftsI: p.V537L

Protein Change: V471G, R504C, F533L, V537L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: meropenemceftazidimeticarcillin
Validation Method: expression in P. aeruginosa PAO1 and MIC testing
Source Database: Reslit

Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.

Research Article

PMID 39287999 · 2024

associated with reduced susceptibility to cefepime-taniborbactam

Mutation Information

ftsI: p.I332V ftsI: c.334ins ftsI: c.999ins

Protein Change: I332V
Nucleotide Change: 334ins, 999ins
Confers Resistance To: cefepimecephalosporins
Validation Method: molecular testing by WGS or PCR and Sanger sequencing; sequencing and MIC testing
Source Database: Reslit

In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii-calcoaceticus Complex Isolates Collected Globally in 2016 and 2017.

Research Article

PMID 31988095 · 2020

ftsI

Mutation Information

ftsI: p.A515V ftsI: p.T526S

Protein Change: A515V, T526S
Organisms: Acinetobacter baumannii
Confers Resistance To: carbapenemssulbactam durlobactam
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Activity of Sulbactam-Durlobactam and Comparators Against a National Collection of Carbapenem-Resistant Acinetobacter baumannii Isolates From Greece.

Research Article

PMID 35127562 · 2021

ftsI

Mutation Information

ftsI: p.A515V ftsI: p.T526S

Protein Change: A515V, T526S
Organisms: Acinetobacter baumannii
Confers Resistance To: carbapenemssulbactam durlobactam
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

In vitro activity of sulbactam-durlobactam against carbapenem-resistant Acinetobacter baumannii and mechanisms of resistance.

Research Article

PMID 35618210 · 2022

ftsI

Mutation Information

ftsI: p.A515V ftsI: p.T526S

Protein Change: A515V, T526S
Organisms: Acinetobacter baumannii
Confers Resistance To: carbapenemssulbactam durlobactam
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Modification of the penicillin-binding-protein 3 as a source of resistance to broad-spectrum cephalosporins in Escherichia coli.

Research Article

PMID 38305674 · 2024

ftsI

Mutation Information

ftsI: p.R335RVPYR

Protein Change: R335RVPYR
Organisms: Escherichia coli
Confers Resistance To: cephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3.

Research Article

PMID 25634992 · 2015

ftsI

Mutation Information

ftsI: p.I336IKYRI ftsI: p.N337NYRIN

Protein Change: I336IKYRI, N337NYRIN
Organisms: Escherichia coli
Confers Resistance To: aztreonamcefiderocolcephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates.

Research Article

PMID 29061754 · 2018

ftsI

Mutation Information

ftsI: p.I336IKYRI

Protein Change: I336IKYRI
Organisms: Escherichia coli
Confers Resistance To: aztreonamcefiderocolcephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Genetic Features Leading to Reduced Susceptibility to Aztreonam-Avibactam among Metallo-β-Lactamase-Producing Escherichia coli Isolates.

Research Article

PMID 32988825 · 2020

ftsI

Mutation Information

ftsI: p.I336IKYRI ftsI: p.I336IPYRI ftsI: p.N337NYRIN

Protein Change: I336IKYRI, I336IPYRI, N337NYRIN
Organisms: Escherichia coli
Confers Resistance To: aztreonamcefiderocolcephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

The Growing Threat of NDM-Producing Escherichia coli With Penicillin-Binding Protein 3 Mutations in the United States-Is There a Potential Role for Durlobactam?

Research Article

PMID 38661186 · 2024

ftsI

Mutation Information

ftsI: p.I336IKYRI ftsI: p.N337NYRIN

Protein Change: I336IKYRI, N337NYRIN
Organisms: Escherichia coli
Confers Resistance To: aztreonamcefiderocolcephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Population Analysis of Escherichia coli Sequence Type 361 and Reduced Cefiderocol Susceptibility, France.

Research Article

PMID 37610183 · 2023

ftsI

Mutation Information

ftsI: p.N337NYRIN

Protein Change: N337NYRIN
Organisms: Escherichia coli
Confers Resistance To: aztreonamcefiderocolcephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Frequencies and mechanisms of mutational resistance to ceftibuten/avibactam in Enterobacterales.

Research Article

PMID 39665271 · 2025

ftsI

Mutation Information

ftsI: p.L350F ftsI: p.G363S ftsI: p.G363V ftsI: p.S365Y ftsI: p.V355G

Protein Change: L350F, G363S, G363V, S365Y, V355G
Organisms: Escherichia coli, Klebsiella pneumoniae
Confers Resistance To: ceftibutenceftibuten avibactam
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Selection and characterization of mutational resistance to aztreonam/avibactam in β-lactamase-producing Enterobacterales.

Research Article

PMID 34568905 · 2021

ftsI

Mutation Information

ftsI: p.A498T

Protein Change: A498T
Organisms: Escherichia coli
Confers Resistance To: cephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Evolution of mutations in the ftsI gene leading to amino acid substitutions in PBP3 in Haemophilus influenzae strains under the selective pressure of ampicillin and cefuroxime.

Research Article

PMID 38954914 · 2024

ftsI

Mutation Information

ftsI: p.V329A ftsI: p.T443A ftsI: p.A502T ftsI: p.N526H ftsI: p.K527N ftsI: p.A530S ftsI: p.T532S

Protein Change: V329A, T443A, A502T, N526H, K527N, A530S, T532S
Organisms: Haemophilus influenzae
Confers Resistance To: cephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Genomic Diversity and Antimicrobial Resistance of Haemophilus Colonizing the Airways of Young Children with Cystic Fibrosis.

Research Article

PMID 34463568 · 2021

ftsI

Mutation Information

ftsI: p.A337V ftsI: p.A368T ftsI: p.M377I ftsI: p.A437S ftsI: p.I449V ftsI: p.G490E

Protein Change: A337V, A368T, M377I, A437S, I449V, G490E
Organisms: Haemophilus influenzae
Confers Resistance To: beta lactams
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Conversion of leukotrienes A4 to C4 in cell-free systems.

Research Article

PMID 3004446 · 1986

ftsI

Mutation Information

ftsI: p.D350N ftsI: p.S357N ftsI: p.S385T ftsI: p.L389F ftsI: p.V562L

Protein Change: D350N, S357N, S385T, L389F, V562L
Organisms: Haemophilus influenzae
Confers Resistance To: cephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Prevalence of macrolide-non-susceptible isolates among β-lactamase-negative ampicillin-resistant Haemophilus influenzae in a tertiary care hospital in Japan.

Research Article

PMID 27530834 · 2016

ftsI

Mutation Information

ftsI: p.R517H

Protein Change: R517H
Organisms: Haemophilus influenzae
Confers Resistance To: beta lactams
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Detection of N526K-substituted penicillin-binding protein 3 conferring low-level mutational resistance to β-lactam antibiotics in Haemophilus influenzae by disc diffusion testing on Mueller-Hinton agar according to EUCAST guidelines.

Research Article

PMID 22389455 · 2012

ftsI

Mutation Information

Protein Change: N526K
Organisms: Haemophilus influenzae
Confers Resistance To: cephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

[Prosthesis for the partially edentulous jaw: a case with the remaining upper left 1st molar and lower 2d premolars, central and lateral incisors and lower left 3d molar].

Research Article

PMID 3895491 · 1985

ftsI

Mutation Information

ftsI: p.G555E ftsI: p.Y557H

Protein Change: N526K
Organisms: Haemophilus influenzae
Confers Resistance To: cephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Cefotaxime-non-susceptibility of Haemophilus influenzae induced by additional amino acid substitutions of G555E and Y557H in altered penicillin-binding protein 3.

Research Article

PMID 30879978 · 2019

ftsI

Mutation Information

Protein Change: G555E, Y557H
Organisms: Haemophilus influenzae
Confers Resistance To: beta lactams
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae.

Research Article

PMID 34551677 · 2021

ftsI

Mutation Information

ftsI: p.L367Q

Protein Change: L367Q
Organisms: Klebsiella pneumoniae
Confers Resistance To: ceftazidime avibactam
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Within-host whole genome analysis of an antibiotic resistant Pseudomonas aeruginosa strain sub-type in cystic fibrosis.

Research Article

PMID 28273168 · 2017

ftsI

Mutation Information

ftsI: p.G63S

Protein Change: G63S
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenems
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.

Research Article

PMID 32071060 · 2020

ftsI

Mutation Information

ftsI: p.Y367C ftsI: p.H394R ftsI: p.N427S ftsI: p.Q458R ftsI: p.Q475R ftsI: p.R504L ftsI: p.V523A ftsI: p.V523M ftsI: p.F533L

Protein Change: Y367C, H394R, N427S, Q458R, Q475R, R504L, V523A, V523M, F533L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenems
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams.

Research Article

PMID 30664925 · 2019

ftsI

Mutation Information

ftsI: p.S368L ftsI: p.A419G ftsI: p.N427L ftsI: p.L434V ftsI: p.A454V ftsI: p.L461V ftsI: p.F507L ftsI: p.S538L

Protein Change: S368L, A419G, N427L, L434V, A454V, L461V, F507L, S538L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenems
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing.

Research Article

PMID 27736752 · 2016

ftsI

Mutation Information

Protein Change: R504C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenems
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Cellular calcium and atherosclerosis: a brief review.

Review

PMID 3066492 · 1988

ftsI

Mutation Information

Protein Change: R504C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenems
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone.

Research Article

PMID 28717172 · 2017

ftsI

Mutation Information

ftsI: p.P527S

Protein Change: P527S
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenems
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.

Research Article

PMID 21135211 · 2010

ftsI

Mutation Information

Protein Change: F533L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbapenems
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

Direct prediction of carbapenem resistance in Pseudomonas aeruginosa by whole genome sequencing and metagenomic sequencing.

Research Article

PMID 37823665 · 2023

ftsI

Mutation Information