ftsW

View on PubMed

cell division protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ftsW

AMR Rules

Browse AMR rules for ftsW

Validation StatusCandidate

Overview

Mechanism: membrane modification
Validation Method: whole-genome sequencing and susceptibility testing
Drug Classes: colistin, cephalosporins
Organisms: Stenotrophomonas maltophilia, Enterococcus faecalis
Papers: 2
Databases: Reslit

Papers2

Antimicrobial Peptide Exposure Selects for Resistant and Fit Stenotrophomonas maltophilia Mutants That Show Cross-Resistance to Antibiotics.

PMID 32999081 · 2020

The study identifies mutations in genes such as mraW, smd_0008, sspb, lptB, wbiI, ftsW, sodB, phoQ, and crp that confer resistance to antimicrobial peptides (AMPs) LL-37, PR-39, and colistin in Stenotrophomonas maltophilia. These mutations lead to cross-resistance to antibiotics and highlight the rapid development of AMP resistance in this opportunistic pathogen.

Gene Information

Gene Name: ftsW
Allele: ftsW
Encodes: cell division protein
Source Database: Reslit
Mechanism: membrane modification
Confers Resistance To: colistin
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: whole-genome sequencing and susceptibility testing
Sequence Accession: NCBI BioProject: PRJNA653015|NC_017671.1

Pbp4 provides transpeptidase activity to the FtsW-PbpB peptidoglycan synthase to drive cephalosporin resistance in Enterococcus faecalis.

PMID 39058024 · 2024

Pbp4 provides transpeptidase activity to the FtsW-PbpB peptidoglycan synthase, which is crucial for cephalosporin resistance in Enterococcus faecalis. PbpB and FtsW are required for this resistance mechanism, and Pbp4 interacts with both to maintain functionality under cephalosporin stress.