Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
outer membrane protein
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R343I | - | modest increase in resistance | Francisella tularensis | doxycyclineciprofloxacin | Reslit | Candidate |
Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation.
Research Article
Deletion of fupA/B in Francisella tularensis increases fluoroquinolone resistance by enhancing outer membrane vesicle secretion and biofilm formation.
Genetic Determinants of Antibiotic Resistance in Francisella.
Review
The paper reviews the genetic determinants of antibiotic resistance in Francisella, focusing on intrinsic resistance mechanisms and the roles of specific genes such as beta-lactamases, efflux pumps, and LPS modification genes.
Mutational Switch-Backs Can Accelerate Evolution of Francisella to a Combination of Ciprofloxacin and Doxycycline.
Research Article
The study identifies mutations in fupA/B, acrAB-TolC, gyrA, and 30S ribosomal subunits that contribute to resistance against ciprofloxacin and doxycycline in Francisella tularensis subsp. holarctica.
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