fur1

uracil phosphoribosyltransferase

Validation StatusCandidate

Overview

Mechanism: non-synonymous mutation
Validation Method: whole-genome sequencing and antifungal susceptibility testing
Organisms: Cryptococcus neoformans
Geographic Location: Eastern China
Papers: 2
Databases: Reslit

Papers2

Molecular Epidemiology and Antifungal Resistance of Cryptococcus neoformans From Human Immunodeficiency Virus-Negative and Human Immunodeficiency Virus-Positive Patients in Eastern China.

PMID 35865921 · 2022

The study identified ERG11 G484S mutation and FUR1 mutations (D42Y, P140S, and A-T transition) as resistance mechanisms in Cryptococcus neoformans isolates from Eastern China.

Gene Information

Gene Name: fur1
Allele: FUR1
Encodes: uracil phosphoribosyltransferase
Source Database: Reslit
Mechanism: non-synonymous mutation
Organisms Tested In: • Cryptococcus neoformans
Geographic Location: Eastern China
Validation Method: whole-genome sequencing and antifungal susceptibility testing
Sequence Accession: PRJCA009353

Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduced susceptibility against 5-fluorocytosine.

PMID 39843955 · 2024

The study identifies mutations in the pyrimidine salvage pathway enzymes FUR1 and FCY1 that contribute to 5-fluorocytosine resistance in Cryptococcus neoformans.

Gene Information

Gene Name: fur1
Allele: FUR1
Encodes: uracil phosphoribosyltransferase
Source Database: Reslit
Organisms Tested In: • Cryptococcus neoformans
Validation Method: genetic transformation and 5-FC susceptibility test
Sequence Accession: PRJNA1000292|PXD044249

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fur1

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