Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
FusB homologue
Overview
Genetic basis of resistance to fusidic acid in staphylococci.
The study identifies two novel genes, fusC and fusD, which encode FusB homologues and confer resistance to fusidic acid in staphylococci. These genes were found in various staphylococcal species, including S. aureus, S. saprophyticus, S. intermedius, and S. lugdunensis.
Genetic basis of resistance to fusidic acid in staphylococci.
Genetic basis of resistance to fusidic acid in staphylococci.
Antibiotic Resistance and the MRSA Problem.
The paper discusses the mechanisms of antibiotic resistance in Staphylococcus aureus, focusing on beta-lactam resistance through the blaZ and mecA genes, glycopeptide resistance via the vanA operon, and resistance to other antibiotics through various genes and mutations.
Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus.
The study identifies various antimicrobial resistance genes in CoNS species, including mecA, norA, vatB, vgaB, lsaB, erm(43), ermT, fusD, fusF, and salA, which confer resistance to beta-lactams, fluoroquinolones, lincosamides, macrolides, streptogramins, fusidic acid, and other antimicrobial agents. These genes are associated with horizontal gene transfer and recombination, highlighting the dynamic nature of CoNS evolution.
Mechanisms of fusidic acid resistance.
The paper discusses three main mechanisms of fusidic acid resistance in Staphylococcus aureus: mutations in the fusA gene encoding EF-G, expression of resistance proteins like FusB, FusC, FusD, and FusF, and mutations in the rplF gene encoding ribosomal protein uL6. These mechanisms involve either direct interference with FA binding, target protection, or disruption of the FA-locked state of EF-G.
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