Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
fusidic acid resistance EF-G-binding protein FusF
Overview
A novel fusidic acid resistance determinant, fusF, in Staphylococcus cohnii.
A novel fusidic acid resistance determinant, fusF, in Staphylococcus cohnii.
A novel fusidic acid resistance determinant, fusF, in Staphylococcus cohnii.
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity.
The study identified several AMR genes in coagulase-negative staphylococci isolates from South Africa and Nigeria, highlighting environmentally driven heterogeneity. Notably, the tetM gene was found in South African isolates but not in Nigerian ones, while cadmium resistance genes were present in Nigerian isolates. Other genes like blaZ, FosB, mecA, FusF, dfrG, ErmA, ErmB, Erm(43), and mphC were also characterized.
Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus.
The study identifies various antimicrobial resistance genes in CoNS species, including mecA, norA, vatB, vgaB, lsaB, erm(43), ermT, fusD, fusF, and salA, which confer resistance to beta-lactams, fluoroquinolones, lincosamides, macrolides, streptogramins, fusidic acid, and other antimicrobial agents. These genes are associated with horizontal gene transfer and recombination, highlighting the dynamic nature of CoNS evolution.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements.
The study identified novel Staphylococcal cassette chromosome mec (SCC mec ) elements in four methicillin-resistant coagulase-negative Staphylococci (CoNS) isolates from healthy medical students. The isolates harbored various antimicrobial resistance genes, including mecA, blaZ, mphC, msrA, tetK, fusC, fusF, qacA, qacB, qacC, norA, copB, arsC, cadC, cadD, copZ, copA, copR, and czcD, which conferred resistance to beta-lactams, macrolides, tetracyclines, fusidic acid, quaternary ammonium compounds, fluoroquinolones, and heavy metals.
Mechanisms of fusidic acid resistance.
The paper discusses three main mechanisms of fusidic acid resistance in Staphylococcus aureus: mutations in the fusA gene encoding EF-G, expression of resistance proteins like FusB, FusC, FusD, and FusF, and mutations in the rplF gene encoding ribosomal protein uL6. These mechanisms involve either direct interference with FA binding, target protection, or disruption of the FA-locked state of EF-G.
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