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fxra

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

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Protein entries specific to fxra

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Overview

Drug Classes: Metronidazole
Organisms: Helicobacter pylori
Papers: 5
Mutations: 25

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
I44F	-	single resistance variant	Helicobacter pylori	Metronidazole	Card Database	Established
V7I	-	single resistance variant	Helicobacter pylori	Metronidazole	Card Database	Established
A32V	-	single resistance variant	Helicobacter pylori	Metronidazole

Papers5

1

Genetic Determinants and Prediction of Antibiotic Resistance Phenotypes in Helicobacter pylori.

PMID 30621024 · 2019

Helicobacter pylori frxA mutation conferring resistance to metronidazole; CARD accession: CARD:3007059

Mutation Information

fxra: p.I44F fxra: p.V7I fxra: p.A32V fxra: p.M149Ter fxra: p.A16T fxra: p.K105Ter fxra: p.S43A fxra: p.M126F fxra: p.A85V fxra: p.A192Ter fxra: p.Y62D fxra: p.I117M

Protein Change: I44F, V7I, A32V, M149Ter, A16T, K105Ter, S43A, M126F, A85V, A192Ter, Y62D, I117M
Organisms: Helicobacter pylori
Confers Resistance To: Metronidazole
Effect on Function: single resistance variant; nonsense mutation
Source Database: Card Database

2

Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal.

PMID 27809767 · 2016

Helicobacter pylori frxA mutation conferring resistance to metronidazole; CARD accession: CARD:3007059

Mutation Information

fxra: p.R106fs fxra: p.A15V fxra: p.R3T fxra: p.P41L fxra: p.R86Ter

Protein Change: R106fs, A15V, R3T, P41L, R86Ter
Organisms: Helicobacter pylori
Confers Resistance To: Metronidazole
Effect on Function: frameshift mutation; single resistance variant; nonsense mutation
Source Database: Card Database

3

Mutations in the Antibiotic Target Genes Related to Clarithromycin, Metronidazole and Levofloxacin Resistance in Helicobacter pylori Strains from Children in China.

PMID 32099422 · 2020

Helicobacter pylori frxA mutation conferring resistance to metronidazole; CARD accession: CARD:3007059

Mutation Information

fxra: p.C13A fxra: p.A48G fxra: p.G441A

Protein Change: C13A, A48G, G441A
Organisms: Helicobacter pylori
Confers Resistance To: Metronidazole
Effect on Function: single resistance variant
Source Database: Card Database

4

Evaluation of frxA and rdxA gene mutations in clinical metronidazole resistance Helicobacter pylori isolates.

PMID 33593015 · 2017

Helicobacter pylori frxA mutation conferring resistance to metronidazole; CARD accession: CARD:3007059

Mutation Information

fxra: p.V9I fxra: p.A70G fxra: p.K97E

Protein Change: V9I, A70G, K97E
Organisms: Helicobacter pylori
Confers Resistance To: Metronidazole
Effect on Function: single resistance variant
Source Database: Card Database

5

Characterisation of the genes encoding resistance to metronidazole (rdxA and frxA) and clarithromycin (the 23S-rRNA genes) in South African isolates of Helicobacter pylori.

PMID 21801504 · 2011

Helicobacter pylori frxA mutation conferring resistance to metronidazole; CARD accession: CARD:3007059

Mutation Information

fxra: p.L39Ter fxra: p.E199Ter

Protein Change: L39Ter, E199Ter
Organisms: Helicobacter pylori
Confers Resistance To: Metronidazole
Effect on Function: nonsense mutation
Source Database: Card Database