gadB

glutamate decarboxylase

Validation StatusCandidate

Overview

Mechanism: potential inactivation of ampicillin
Validation Method: over-expression in E. coli and determination of antibiotic resistance
Drug Classes: Ampicillin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Epigenetic inheritance based evolution of antibiotic resistance in bacteria.

PMID 18282299 · 2008

The study identifies AmpC, GadA, and GadB as genes involved in epigenetic-based antibiotic resistance in E. coli, demonstrating that gene expression changes can lead to resistance without DNA mutations. Additionally, the DNA methyltransferase dam was found to influence resistance to nalidixic acid.

Gene Information

Gene Name: gadB
Allele: GadB
Encodes: glutamate decarboxylase
Source Database: Reslit
Mechanism: potential inactivation of ampicillin
Confers Resistance To: Ampicillin
Organisms Tested In: • Escherichia coli
Validation Method: over-expression in E. coli and determination of antibiotic resistance

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gadB

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