glnA

glutamine synthetase

Validation StatusCandidate

Overview

Mechanism: N-acetylation of norfloxacin
Validation Method: cloning and heterologous expression in E. coli, enzyme activity assays, and disk diffusion assay
Drug Classes: Fluoroquinolone
Organisms: Microbacterium sp. strain 4N2-2, Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Identification of the enzyme responsible for N-Acetylation of Norfloxacin by Microbacterium sp. Strain 4N2-2.

PMID 23104417 · 2013

The study identifies glutamine synthetase (glnA) from Microbacterium sp. strain 4N2-2 as the enzyme responsible for N-acetylation of norfloxacin, leading to low-level resistance against fluoroquinolones.

Gene Information

Gene Name: glnA
Allele: glnA
Encodes: glutamine synthetase
Source Database: Reslit
Mechanism: N-acetylation of norfloxacin
Confers Resistance To: Fluoroquinolone
Organisms Tested In: • Microbacterium sp. strain 4N2-2
• Escherichia coli
Validation Method: cloning and heterologous expression in E. coli, enzyme activity assays, and disk diffusion assay
Sequence Accession: JX901058

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glnA

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