glnpq

Amino acid ATP-binding cassette transport system

Validation StatusCandidate

Overview

Mechanism: Loss-of-function mutations in GlnPQ restore CEF resistance in the cdaA-1 strain
Validation Method: Genetic studies and disk diffusion assay
Drug Classes: Cefuroxime
Organisms: Lactococcus lactis
Papers: 1
Databases: Reslit

Papers1

Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis.

Mutations in kupB and glnPQ restore cefuroxime resistance in cdiA mutants of Lactococcus lactis by reducing intracellular osmolyte levels.

Gene Name: glnpq
Allele: glnPQ
Encodes: Amino acid ATP-binding cassette transport system
Source Database: Reslit
Mechanism: Loss-of-function mutations in GlnPQ restore CEF resistance in the cdaA-1 strain
Confers Resistance To: Cefuroxime
Organisms Tested In: • Lactococcus lactis
Validation Method: Genetic studies and disk diffusion assay

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