glyA

View on PubMed

serine hydroxymethyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to glyA

AMR Rules

Browse AMR rules for glyA

Validation StatusCandidate

Overview

Validation Method: knockout experiments and MIC testing
Drug Classes: trimethoprim
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

A Strategic Target Rescues Trimethoprim Sensitivity in Escherichia coli.

PMID 32240953 · 2020

The study identifies glyA as an emergent vulnerability associated with trimethoprim resistance in E. coli. Deletion of glyA significantly reduces trimethoprim resistance in both laboratory-evolved and clinical isolates.

Gene Information

Gene Name: glyA
Allele: glyA
Encodes: serine hydroxymethyltransferase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Validation Method: knockout experiments and MIC testing

Comments (0)

No comments yet. Be the first to comment!

glyA

Gene Information

Browse AMR Genes

glyA

Gene Information