guaA

Overview

Drug Classes: Oxacillin|Penicillin|Amoxicillin/clavulanic acid|Ceftaroline, Gentamicin
Organisms: Staphylococcus aureus, Escherichia coli
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	G109C	-	Staphylococcus aureus	Oxacillin\|Penicillin\|Amoxicillin/clavulanic acid\|Ceftaroline	Reslit	Candidate
-	TTG->TGT	inactivation	Escherichia coli	Gentamicin	Reslit	Candidate

Papers2

In Vitro Selection of High-Level Beta-Lactam Resistance in Methicillin-Susceptible Staphylococcus aureus.

Detected in SA0937 strain after 15 passages

Nucleotide Change: G109C
Organisms: Staphylococcus aureus
Confers Resistance To: Oxacillin|Penicillin|Amoxicillin/clavulanic acid|Ceftaroline
Source Database: Reslit

Evolutionary trajectories determine feasibility of collateral sensitivity-based antibiotic treatment strategies in critical bacterial pathogens.

Mutation in guaA leads to collateral sensitivity to gentamicin.