hemB

5-aminolevulinate dehydratase

Validation StatusCandidate

Overview

Mechanism: mutation
Validation Method: genomic and complementation analyses
Drug Classes: Cefiderocol, Gentamicin, Kanamycin
Organisms: Escherichia coli, Staphylococcus aureus
Papers: 4
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P249L	-	-	Staphylococcus aureus	Gentamicin	Reslit	Candidate
G87D	-	-	Staphylococcus aureus	Kanamycin	Reslit	Candidate

Papers4

Generation of Small Colony Variants in Biofilms by Escherichia coli Harboring a Conjugative F Plasmid.

PMID 28302951 · 2017

The study identifies that the insertion of Tn 1000 into the hemB gene in E. coli leads to the emergence of small colony variants (SCVs) with increased resistance to aminoglycoside antibiotics.

Gene Information

Gene Name: hemB
Allele: hemB
Encodes: 5-aminolevulinate dehydratase
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: genomic and complementation analyses
Sequence Accession: NC_000913

Genomic Modification of TonB and Emergence of Small-Colony Phenotype in VIM- and NDM-Producing Escherichia coli following Cefiderocol Exposure In Vitro.

PMID 37022155 · 2023

The study identifies mutations in the tonB gene and hem genes associated with cefiderocol resistance in VIM- and NDM-producing Escherichia coli. These mutations contribute to the emergence of small-colony variants, which are linked to reduced susceptibility to antibiotics.

Gene Information

Gene Name: hemB
Allele: hemB
Encodes: proteins involved in heme biosynthesis
Source Database: Reslit
Mechanism: mutation
Confers Resistance To: Cefiderocol
Organisms Tested In: • Escherichia coli
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA750050|PRJNA822923|PRJNA925002

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hemB

Mutations

Gene Information

Gene Information