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hpaC

flavin reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to hpaC

Browse AMR rules for hpaC

Validation StatusCandidate

Overview

Mechanism: HpaC promotes SPN sensitivity independently of the T4p
Validation Method: genomic sequencing and functional assays
Organisms: Neisseria gonorrhoeae
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	G277T	-	Neisseria gonorrhoeae	-	Reslit	Candidate

Papers1

1

Flavin affinity for the reductase HpaC differentially sensitizes Neisseria gonorrhoeae during Type IV pilus-dependent killing.

PMID 41144484 · 2025

Gene Information

Gene Name: hpaC
Allele: hpaC
Encodes: flavin reductase
Source Database: Reslit
Mechanism: HpaC promotes SPN sensitivity independently of the T4p
Organisms Tested In: • Neisseria gonorrhoeae
Validation Method: genomic sequencing and functional assays

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