hsdM

restriction modification system component

Validation StatusSupported

Overview

Mechanism: methylation of DNA
Validation Method: sequencing
Drug Classes: Isoniazid, Rifampicin, Ethambutol, Para-aminosalicylic acid
Organisms: Staphylococcus aureus, Mycobacterium bovis BCG, Mycobacterium tuberculosis, Mycobacterium smegmatis
Papers: 3
Databases: Reslit

Papers3

Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.

PMID 15213324 · 2004

The study identified resistance genes such as blaZ, mecA, and far1 in Staphylococcus aureus strains, highlighting the role of mobile genetic elements in the spread of drug resistance.

Gene Information

Gene Name: hsdM
Allele: hsdM
Encodes: restriction modification system component
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
Validation Method: sequencing
Sequence Accession: NC_002950|NC_003923|BX571856|BX571857|BX571858

The Mycobacterial DNA Methyltransferase HsdM Decreases Intrinsic Isoniazid Susceptibility.

PMID 34827261 · 2021

The study identifies HsdM as a DNA methyltransferase that decreases intrinsic isoniazid susceptibility in Mycobacterium bovis BCG and Mycobacterium tuberculosis by modifying gene expression through DNA methylation.

Gene Information

Gene Name: hsdM
Allele: hsdM
Encodes: adenine methyltransferase
Source Database: Reslit
Mechanism: methylation of DNA
Confers Resistance To: Isoniazid
Organisms Tested In: • Mycobacterium bovis BCG
• Mycobacterium tuberculosis
Validation Method: construction of hsdM knockout strain and assessment of antibiotic susceptibility
Sequence Accession: NCBI:CP063215|NCBI:CP063216|NCBI:CP063217

DNA Methyltransferase HsdM Induce Drug Resistance on Mycobacterium tuberculosis via Multiple Effects.

PMID 34943756 · 2021

The study shows that the DNA methyltransferase HsdM affects drug resistance in Mycobacterium tuberculosis by modulating gene expression of redox, drug targets, and transporters, and increasing mutation rates.

Gene Information

Gene Name: hsdM
Allele: hsdM
Encodes: DNA methyltransferase
Source Database: Reslit
Mechanism: modulates gene expression of redox, drug targets and transporters, and gene mutation
Confers Resistance To: IsoniazidRifampicinEthambutolPara-aminosalicylic acid
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium smegmatis
Validation Method: knockout experiments and drug susceptibility tests

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