Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

infB

translation initiation factor

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to infB

AMR Rules

Browse AMR rules for infB

Validation StatusSupported

Overview

Mechanism: macrolide resistance
Validation Method: TraDIS-Xpress analysis showing selective advantage in triclosan for mutants with insertions immediately upstream of infB
Drug Classes: Triclosan, Macrolide, Clarithromycin
Organisms: Escherichia coli, Helicobacter pylori
Geographic Location: Eastern China|China
Papers: 6
Databases: Reslit
Mutations: 5

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T37I	-	-	Helicobacter pylori	Clarithromycin	Reslit	Candidate
-	A184G	-	Helicobacter pylori	Clarithromycin	Reslit	Candidate
-	A412G	-	Helicobacter pylori	Clarithromycin

Papers6

TraDIS-Xpress: a high-resolution whole-genome assay identifies novel mechanisms of triclosan action and resistance.

PMID 32051187 · 2020

The study identified several genes involved in triclosan resistance, including fabI, acrAB, ompF, marR, soxS, rpoN, pcnB, infB, lon, rbsB, and trkHA. These genes were found to play roles in triclosan sensitivity through various mechanisms such as efflux pumps, porins, and stress response regulation.

Gene Information

Gene Name: infB
Allele: infB
Encodes: translation initiation factor
Source Database: Reslit
Confers Resistance To: Triclosan
Organisms Tested In: • Escherichia coli
Validation Method: TraDIS-Xpress analysis showing selective advantage in triclosan for mutants with insertions immediately upstream of infB

Environmental complexity is more important than mutation in driving the evolution of latent novel traits in E. coli.

PMID 36202805 · 2022

Complex antibiotic environments drive the evolution of latent novel traits in E. coli through the spread of pleiotropic mutations affecting multiple resistance mechanisms.

Gene Information

Gene Name: infB
Allele: infB
Encodes: translation initiation factor IF-2
Source Database: Reslit
Mechanism: macrolide resistance
Confers Resistance To: Macrolide
Organisms Tested In: • Escherichia coli
Validation Method: genomic sequencing and phenotyping

Genomic insights into antibiotic resistance, virulence traits and phylogenetic lineages of 141 clinical Helicobacter pylori isolates from Eastern China.

PMID 41561082 · 2025

The study identified several AMR genes and mutations in 141 clinical Helicobacter pylori isolates from Eastern China, including 23S rRNA (A2143G), infB (C110T), gyrA (T261A), gyrB (G1033A), pbp1A (1785_1786insAGC), rdxA (G278A), frxA (T184A), recA (G946A), 16S rRNA (A928C), and oorD (G22A) associated with resistance to clarithromycin, levofloxacin, amoxicillin, metronidazole, tetracycline, and furazolidone.

Gene Information

Gene Name: infB
Allele: infB
Encodes: translation initiation factor
Source Database: Reslit
Confers Resistance To: Clarithromycin
Organisms Tested In: • Helicobacter pylori
Geographic Location: Eastern China|China
Validation Method: whole-genome sequencing and phenotypic antimicrobial susceptibility testing
Sequence Accession: NMDC10020204