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adenosine 1408 aminoglycoside-resistance rRNA methyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| kamB | Card DatabaseResFinder DatabaseReslit | 6 | Kanamycin, Neomycin +6 | E. coli +4 | - | 2011, 2022, 2025 |
| WP_063964000.1 |
| KamB | Reference Gene Catalog | 1 | AMINOGLYCOSIDE | Streptoalloteichus tenebrarius, Streptoalloteichus hindustanus | - | - | AJ629123.1, AJ875019.1 | - |
Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies.
The study describes the expression, purification, and crystallization of KamB and NpmA, two adenosine 1408 aminoglycoside-resistance rRNA methyltransferases, which confer resistance to aminoglycosides such as kanamycin, neomycin, and apramycin.
Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens.
The study characterizes the biological cost of 16S rRNA methyltransferases (ArmA, RmtA, RmtB, RmtC, RmtD, Sgm, KamB, and NpmA) in Escherichia coli, demonstrating their role in conferring high-level aminoglycoside resistance and their impact on bacterial fitness, translational fidelity, and stress response.
Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens.
The study characterizes the biological cost of 16S rRNA methyltransferases (ArmA, RmtA, RmtB, RmtC, RmtD, Sgm, KamB, and NpmA) in Escherichia coli, demonstrating their role in conferring high-level aminoglycoside resistance and their impact on bacterial fitness, translational fidelity, and stress response.
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