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kasA

3-oxoacyl-[acyl-carrier-protein] synthase, KASII

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Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to kasA

Browse AMR rules for kasA

Validation StatusSupported

Overview

Validation Method: genomic analysis
Drug Classes: Isoniazid, Triclosan
Organisms: Enterococcus durans, Enterococcus gallinarum, Mycobacterium tuberculosis, Ornithobacterium hominis
Geographic Location: Egypt, Ethiopia, South Africa
Papers: 13
Databases: Reslit
Mutations: 12

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
F413L	-	single resistance variant	Mycobacterium tuberculosis	Isoniazid	Card DatabaseResFinder Database	Confirmed
G269S	G805A	single resistance variant	Mycobacterium tuberculosis	Isoniazid	Card DatabaseResFinder DatabaseReslit	Confirmed

Papers13

1

Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.

PMID 33178155 · 2020

The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.

Gene Information

Gene Name: kasA
Allele: kasA
Encodes: 3-oxoacyl-[acyl-carrier-protein] synthase, KASII
Source Database: Reslit
Confers Resistance To: IsoniazidTriclosan
Organisms Tested In: • Enterococcus durans
• Enterococcus gallinarum
Geographic Location: South Africa
Validation Method: genomic analysis
Sequence Accession: MK086097|MK086099

2

Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis.

PMID 36504241 · 2022

The study identified specific SNPs in genes associated with isoniazid resistance (katG, inhA, fabG1, kasA) and rifampicin resistance (rpoB, rpoC) in Mycobacterium tuberculosis, demonstrating the emergence of genotypic resistance under varying drug concentrations.

Gene Information

Gene Name: kasA
Allele: kasA
Encodes: ketosynthase
Source Database: Reslit
Confers Resistance To: Isoniazid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: whole genome sequencing

3

Draft genome sequence of novel Candidatus Ornithobacterium hominis carrying antimicrobial resistance genes in Egypt.

PMID 38302869 · 2024

The study presents the draft genome sequence of Candidatus Ornithobacterium hominis, highlighting the presence of multiple antimicrobial resistance genes, including those conferring resistance to sulfonamides, aminoglycosides, fluoroquinolones, and others. Key genes identified include oxyR, gidB, murA, rpoB, gyrA, and others, which were experimentally validated for their resistance mechanisms.

Gene Information

Gene Name: kasA
Allele: kasA
Encodes: 3-oxoacyl-[acyl-carrier-protein] synthase, KASII
Source Database: Reslit
Confers Resistance To: IsoniazidTriclosan
Organisms Tested In: • Ornithobacterium hominis
Geographic Location: Egypt
Validation Method: experimental validation
Sequence Accession: WP_119059582.1|WP_119058480.1|WP_283670756.1|WP_119057766.1|WP_119058897.1|WP_119058034.1|WP_119057337.1|WP_119057769.1|WP_119059585.1|WP_119058444.1|WP_119057768.1|WP_119059381.1|WP_283671279.1|WP_119058724.1|WP_283671350.1|WP_283671268.1|WP_119058163.1|SZD73303.1|WP_283670346.1|WP_119059468.1

4

Drug resistance profile of Mycobacterium tuberculosis complex isolated from pulmonary tuberculosis patients and their household contacts in central Ethiopia.

PMID 40542339 · 2025

The study identified genes katG, inhA, aphC, and kasA associated with isoniazid resistance in Mycobacterium tuberculosis. Mutations in katG were linked to INH resistance.

Gene Information

Gene Name: kasA
Allele: kasA
Encodes: Enzyme involved in isoniazid resistance
Source Database: Reslit
Confers Resistance To: Isoniazid
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Ethiopia
Validation Method: Xpert MTB/XDR assay and phenotypic drug susceptibility testing