katA

catalase

Validation StatusSupported

Overview

Mechanism: frameshift mutation leading to premature truncation
Validation Method: expression in E. coli and resistance assays
Drug Classes: Fluoroquinolone
Organisms: Staphylococcus epidermidis, Escherichia coli, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus subsp. aureus, Staphylococcus aureus
Papers: 5
Databases: Reslit

Papers5

Catalases are NAD(P)H-dependent tellurite reductases.

PMID 17183702 · 2006

The study identifies the katA gene from Staphylococcus epidermidis as encoding a catalase that exhibits NADH-dependent tellurite reductase activity, conferring resistance to tellurite in E. coli.

Gene Information

Gene Name: katA
Allele: katA
Encodes: catalase
Source Database: Reslit
Organisms Tested In: • Staphylococcus epidermidis
• Escherichia coli
Validation Method: expression in E. coli and resistance assays
Sequence Accession: DQ301862

The role of catalase in gonococcal resistance to peroxynitrite.

PMID 22117004 · 2012

The study identifies katA as a gene encoding catalase that provides resistance to peroxynitrite in Neisseria gonorrhoeae. The resistance is attributed to the catalytic activity of KatA, which detoxifies peroxynitrite, and the study shows that the absence of katA leads to increased sensitivity to peroxynitrite.

Gene Information

Gene Name: katA
Allele: katA
Encodes: catalase
Source Database: Reslit
Organisms Tested In: • Neisseria gonorrhoeae
• Neisseria meningitidis
Validation Method: experimental validation through construction of a katA mutant and restoration of resistance via IPTG induction of a cloned katA gene

Molecular characterization of a catalase-negative methicillin-susceptible Staphylococcus aureus subsp. aureus strain collected from a patient with cutaneous abscess.

PMID 24131694 · 2014

A catalase-negative methicillin-susceptible Staphylococcus aureus subsp. aureus strain was characterized, with a thymine insertion in the katA gene causing a frameshift mutation and premature truncation of catalase to 21 amino acids.

Gene Information

Gene Name: katA
Allele: katA
Encodes: catalase
Source Database: Reslit
Mechanism: frameshift mutation leading to premature truncation
Organisms Tested In: • Staphylococcus aureus subsp. aureus
Validation Method: sequencing of the katA gene
Sequence Accession: D83357

Molecular Characterization of a Catalase-Negative Staphylococcus aureus Blood Culture Isolate.

PMID 26354811 · 2015

A catalase-negative Staphylococcus aureus isolate was characterized, revealing a 2-bp insertion in the katA gene causing a frameshift mutation and a truncated protein, leading to loss of catalase activity.

Gene Information

Gene Name: katA
Allele: katA
Encodes: catalase
Source Database: Reslit
Mechanism: frameshift mutation leading to truncated protein
Organisms Tested In: • Staphylococcus aureus
Validation Method: sequencing analysis
Sequence Accession: FR821777.2

ArcR contributes to tolerance to fluoroquinolone antibiotics by regulating katA in Staphylococcus aureus.

PMID 36910210 · 2023

ArcR regulates katA expression, which is crucial for bacterial tolerance to oxidative stress and fluoroquinolone antibiotics.

Gene Information

Gene Name: katA
Allele: katA
Encodes: catalase
Source Database: Reslit
Confers Resistance To: Fluoroquinolone
Organisms Tested In: • Staphylococcus aureus
Validation Method: overexpression in ΔarcR mutant restored bacterial resistance to oxidative stress and antibiotics

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