kmrA

MFS-type transporter

Validation StatusCandidate

Overview

Validation Method: plasmid cloning and MIC testing
Drug Classes: Cefepime, Ceftazidime, Chloramphenicol
Organisms: Klebsiella pneumoniae
Papers: 2
Databases: Reslit

Papers2

Efflux-mediated drug resistance in bacteria: an update.

PMID 19678712 · 2009

The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.

Gene Information

Gene Name: kmrA
Allele: kmrA
Encodes: MFS-type transporter
Source Database: Reslit
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: plasmid cloning and MIC testing

Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044.

PMID 22496764 · 2012

The CpxAR two-component system contributes to resistance against cefepime and chloramphenicol in Klebsiella pneumoniae NTUH-K2044 by modulating efflux pump expression and outer membrane protein profiles.

Gene Information

Gene Name: kmrA
Allele: kmrA
Encodes: major facilitator (MFS) type efflux pump
Source Database: Reslit
Confers Resistance To: CefepimeCeftazidimeChloramphenicol
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: quantitative real-time RT-PCR and expression analysis
Sequence Accession: BAH60994.1|YP_002917062.1

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kmrA

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