Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
16S rRNA methyltransferase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G110E | - | - | Mycoplasma mycoides | Kasugamycin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession |
|---|
| Protein Accession |
|---|
| ksgA | Reslit | 12 | Kasugamycin, Streptomycin +2 | Bacillus subtilis +12 | Hong Kong, Iraq, Taiwan, China | 2009, 2011, 2012, 2020, 2024, 2025 | 3FUT|3FUU|3FUV|3FUW|3FUX | - |
| ksga | Reslit | 3 | Aminoglycoside, Kasugamycin | Escherichia coli +2 | China, Europe | 2020, 2025 | MT820501|PRJNA668015 | - |
Inactivation of KsgA, a 16S rRNA Methyltransferase, Causes Vigorous Emergence of Mutants with High-Level Kasugamycin Resistance.
Inactivation of the ksgA gene, which encodes a 16S rRNA methyltransferase, leads to high-level resistance to kasugamycin in Bacillus subtilis and Escherichia coli. Mutations in ksgA result in a significant increase in the frequency of high-level kasugamycin-resistant mutants.
ksgA mutations confer resistance to kasugamycin in Neisseria gonorrhoeae.
Mutations in the ksgA gene confer resistance to kasugamycin in Neisseria gonorrhoeae. These mutations include point mutations, deletions, duplications, and insertions, and were experimentally validated through sequencing and transformation assays.
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine.
The study characterizes the KsgA methyltransferase from Thermus thermophilus, showing that it methylates A1518 and A1519 of 16S rRNA, and that loss of this dimethylation confers resistance to kasugamycin.
The chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness.
The study shows that deletion of the ksgA gene in E. coli leads to increased resistance to kasugamycin. Additionally, the ksgA gene was cloned and expressed in various strains, confirming its role in resistance mechanisms.
Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis.
The study identifies several β-lactam resistance genes, including ampC, lacA, pbp2, pbp3, pbp4a, pbp6a, and pbp7, as well as multidrug efflux pumps such as acrAB-tolC, acrAD-tolC, mdtABC-tolC, emrAB-tolC, mexAB-oprM, and others. Additionally, genes like bacA, ksgA, crcB, and rarD are implicated in resistance to bacitracin, kasugamycin, streptomycin, camphor, and chloramphenicol, respectively.
Response of methicillin-resistant Staphylococcus aureus to amicoumacin A.
The study identifies mutations in ksgA, fusA, dnaG, lacD, SACOL0611, SACOL0187, and oppB that confer resistance to amicoumacin A in methicillin-resistant Staphylococcus aureus.
Characteristics of plasmids in multi-drug-resistant Enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq.
The study identified various plasmid-borne antimicrobial resistance genes in multi-drug-resistant Enterobacteriaceae isolates from a newly opened hospital in Iraq, including aminoglycoside, beta-lactam, sulfamethoxazole/trime-thoprim, tetracycline, and chloramphenicol resistance genes.
Whole-genome sequencing and identification of Morganella morganii KT pathogenicity-related genes.
The study identified several AMR genes in Morganella morganii KT, including ampC, metallo-beta-lactamase genes (MM2254, MM2308, MM2606), tetAJ, catA2, bcr, and ksgA, which confer resistance to various antibiotics such as beta-lactams, carbapenems, tetracycline, chloramphenicol, bicyclomycin, and kasugamycin.
Whole-genome sequence analyses of Glaesserella parasuis isolates reveals extensive genomic variation and diverse antibiotic resistance determinants.
The study identified several antibiotic resistance genes in Glaesserella parasuis, including bla ROB−1, aac(6′)-Ie-aph(2″)-Ia, sul2, aph(3′)-Ib, norA, bacA, ksgA, and bcr, which contribute to resistance against beta-lactams, aminoglycosides, sulfonamides, fluoroquinolones, and multiple antibiotics.
Isolation and characterization of Uropathogenic Escherichia coli (UPEC) from red panda (Ailurus fulgens).
The study identified a Uropathogenic Escherichia coli (UPEC) strain isolated from a red panda that exhibited resistance to multiple antibiotics, including aminoglycosides, beta-lactams, and macrolides. The strain possessed 20 resistance genes, such as acra, acrb, mdte, mdtf, mdtn, mdto, mdtp, tolc, arna, baca, bcr, bl1_ec, emre, ksga, macb, mdfa, mdtg, mdth, mdtk, and mdtl, which contribute to multidrug resistance.
A novel pathogenic species of genus Stenotrophomonas: Stenotrophomonas pigmentata sp. nov.
The study identifies a novel pathogenic species, Stenotrophomonas pigmentata sp. nov., which exhibits resistance to multiple antibiotics, including β-lactams, carbapenems, and trimethoprim-sulfamethoxazole. Several multidrug resistance efflux pump and antibiotic resistance genes were found in its genome.
16S rRNA methyltransferase KsgA contributes to oxidative stress and antibiotic resistance in Pseudomonas aeruginosa.
The study identifies KsgA as a 16S rRNA dimethyltransferase that methylates adenine at positions 1518/1519 in 16S rRNA. The ksgA mutant exhibits increased sensitivity to menadione, hygromycin B, and tylosin, and resistance to kasugamycin.
Two dynamic N-terminal regions are required for function in ribosomal RNA adenine dimethylase family members.
Stenotrophomonas tuberculopleuritidis sp. nov., a novel pathogenic Stenotrophomonas species isolated from tuberculous pleurisy patient.
The study identifies multiple antibiotic resistance genes in Stenotrophomonas tuberculopleuritidis sp. nov., including beta-lactamases, aminoglycoside resistance genes, and efflux pump genes, highlighting its multidrug-resistant nature and potential clinical significance.
Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential.
The study identified 10 antibiotic resistance genes in the Actinobacillus pleuropneumoniae strain APPFJLYC01, including genes conferring resistance to multiple antibiotic classes such as β-lactams, tetracyclines, aminoglycosides, and macrolides.
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