Browse AMR Genes

Explore antimicrobial resistance genes from the literature

lafB

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to lafB

Browse AMR rules for lafB

Overview

Drug Classes: Daptomycin
Organisms: Enterococcus faecium, E. faecium
Papers: 2
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
W193R	C577T T577C	reduces the stability of EfLafB, loss of function	Enterococcus faecium, E. faecium	Daptomycin	Reslit	Candidate

Papers2

1

Exploring Daptomycin Hypersensitivity in Enterococcus faecium: The Impact of LafB Mutation on Bacterial Virulence.

PMID 40649721 · 2025

The W193R mutation in lafB leads to daptomycin hypersusceptibility and reduced virulence in E. faecium.

Mutation Information

Protein Change: W193R
Organisms: Enterococcus faecium
Confers Resistance To: Daptomycin
Effect on Function: reduces the stability of EfLafB
Source Database: Reslit

2

Loss of LafB activity reverses daptomycin resistance in E. faecium.

PMID 41313008 · 2026

Mutations in lafB lead to daptomycin hypersusceptibility.

Mutation Information

lafB: p.W193R / c.C577T

Protein Change: W193R
Nucleotide Change: C577T
Organisms: E. faecium
Confers Resistance To: Daptomycin
Effect on Function: loss of function
Source Database: Reslit