lexA

LexA repressor

Validation StatusCandidate

Overview

Mechanism: inhibition of autoproteolysis
Validation Method: mutation assay and MIC determination
Drug Classes: Ciprofloxacin, Ciprofloxacin|Levofloxacin
Organisms: Escherichia coli, Mycobacterium tuberculosis, Pseudomonas aeruginosa
Papers: 4
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S119A	-	-	Escherichia coli	Ciprofloxacin	Reslit	Candidate
S125A	C374A	-	Pseudomonas aeruginosa, Escherichia coli	Ciprofloxacin\|Levofloxacin	Reslit	Candidate

Papers4

Inhibition of mutation and combating the evolution of antibiotic resistance.

PMID 15869329 · 2005

The study shows that preventing LexA cleavage inhibits the evolution of resistance to ciprofloxacin and rifampicin in E. coli by blocking the SOS response and subsequent mutagenesis.

Gene Information

Gene Name: lexA
Allele: lexA
Encodes: LexA repressor
Source Database: Reslit
Confers Resistance To: Ciprofloxacin
Organisms Tested In: • Escherichia coli
Validation Method: mutation assay and MIC determination
Sequence Accession: NT01EC2662|NT01EC4829

Anti-mutagenic agent targeting LexA to combat antimicrobial resistance in mycobacteria.

PMID 39122002 · 2024

The study identifies 3-nitrophenyl boronic acid (3-nPBA) as a novel inhibitor of Mycobacterium tuberculosis LexA, which suppresses the SOS response and reduces antimicrobial resistance by preventing LexA autoproteolysis and stabilizing its DNA binding.

Gene Information

Gene Name: lexA
Allele: lexA
Encodes: transcriptional repressor
Source Database: Reslit
Mechanism: inhibition of autoproteolysis
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: isothermal titration calorimetry, molecular dynamics simulations, autoproteolysis assays

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lexA

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