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liaR

LiaFSR signaling pathway regulator

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NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to liaR

Browse AMR rules for liaR

Validation StatusSupported

Overview

Mechanism: cell envelope stress response
Validation Method: whole-genome sequencing and allelic frequency measurements
Drug Classes: Daptomycin, DAPTOMYCIN
Organisms: Enterococcus faecalis, Listeria monocytogenes, Enterococcus faecium, Streptococcus mutans
Geographic Location: China, Europe, Switzerland
Papers: 26
Databases: Reslit
Mutations: 8

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
W73C	G221T T218C	single resistance variant, constitutive activation, response regulator transcription factor LiaR, mutated	Enterococcus faecium	DaptomycinDAPTOMYCIN	Card DatabaseReference Gene CatalogReslit	Confirmed
T120A	-	-	Enterococcus faecium, Enterococcus faecalis	Daptomycin	Reslit	Candidate

Papers26

1

Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance.

PMID 23959318 · 2013

The study identified mutations in the liaF, liaR, yvlB, and cls genes that contribute to daptomycin resistance in Enterococcus faecalis through a defined evolutionary pathway involving the LiaFSR signaling pathway and changes in membrane composition.

Gene Information

Gene Name: liaR
Allele: liaR
Encodes: LiaFSR signaling pathway regulator
Source Database: Reslit
Mechanism: cell envelope stress response
Confers Resistance To: Daptomycin
Organisms Tested In: • Enterococcus faecalis
Validation Method: whole-genome sequencing and allelic frequency measurements
Sequence Accession: SRP029594

2

Enterococcus faecalis Adapts to Antimicrobial Conjugated Oligoelectrolytes by Lipid Rearrangement and Differential Expression of Membrane Stress Response Genes.

PMID 32117172 · 2020

Enterococcus faecalis develops resistance to conjugated oligoelectrolytes (COEs) through mutations in the liaFSR system, specifically liaF (Ile179 deletion) and liaR (A98V), leading to reduced susceptibility to COE1-3C and COE1-3Py, respectively.

Gene Information

Gene Name: liaR
Allele: liaR
Encodes: a component of the LiaFSR three-component system
Source Database: Reslit
Mechanism: mutation-induced resistance to COE1-3Py
Organisms Tested In: • Enterococcus faecalis
Validation Method: complementation studies

3

Mechanisms of Bacteriocin Resistance in Listeria monocytogenes

PMID 39858597 · 2023

This review discusses the mechanisms of bacteriocin resistance in Listeria monocytogenes, focusing on modifications of bacteriocin docking receptors, changes in cell wall and membrane structure, and cross-resistance to different bacteriocins.

Gene Information

Gene Name: liaR
Allele: liaR
Encodes: response regulator
Source Database: Reslit
Organisms Tested In: • Listeria monocytogenes
Geographic Location: Europe
Validation Method: mutant analysis

4

Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.

PMID 40775271 · 2025

The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).

Gene Information

Gene Name: liaR
Allele: liaR
Encodes: two-component system response regulator
Source Database: Reslit
Organisms Tested In: • Enterococcus faecalis
Geographic Location: China
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA1241515

5

Emergence of vancomycin-resistant Enterococcus faecium vanA ST612 with reduced daptomycin susceptibility, Switzerland, 2018 to 2024.

PMID 41234193 · 2025

The study identifies mutations in liaR (W73C) and liaS (T120A) associated with reduced daptomycin susceptibility in vancomycin-resistant Enterococcus faecium vanA ST612. It also characterizes resistance genes including vanA, aac(6')-I, msr(C), and ant(6)-Ia.

Gene Information

Gene Name: liaR
Allele: liaR
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: mutation
Confers Resistance To: Daptomycin
Organisms Tested In: • Enterococcus faecium
Geographic Location: Switzerland
Validation Method: genomic analysis and MIC testing