Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component system histidine kinase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| H264Q | - | single resistance variant, sensor histidine kinase LiaS | Enterococcus faecium | DaptomycinDAPTOMYCIN | Card DatabaseReference Gene Catalog | Confirmed |
| T120A | single resistance variant, sensor histidine kinase LiaS | Enterococcus faecium | DaptomycinDAPTOMYCIN | Card DatabaseReference Gene Catalog |
| Confirmed |
| A180T | - | single resistance variant, sensor histidine kinase LiaS | Enterococcus faecalis, Enterococcus faecium | DaptomycinDAPTOMYCIN | Card DatabaseReference Gene Catalog | Confirmed |
| K214R | - | - | Streptococcus pyogenes | - | Reslit | Candidate |
| T120S | - | Enterococcus faecium | Daptomycin | Reslit | Candidate |
| E192G | - | single resistance variant, sensor histidine kinase LiaS | Enterococcus faecium | DaptomycinDAPTOMYCIN | Card DatabaseReference Gene Catalog | Confirmed |
| G92D | - | sensor histidine kinase LiaS | Enterococcus faecium | DAPTOMYCIN | Reference Gene Catalog | Established |
| - | - | Enterococcus faecium | Daptomycin | Reslit | Candidate |
Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility in Enterococcus faecalis.
Arginine metabolism in Enterococcus faecalis leads to increased aggregation, decreased biofilm formation, and altered antibiotic susceptibility, particularly to ampicillin and ceftriaxone.
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.
The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).
Emergence of vancomycin-resistant Enterococcus faecium vanA ST612 with reduced daptomycin susceptibility, Switzerland, 2018 to 2024.
The study identifies mutations in liaR (W73C) and liaS (T120A) associated with reduced daptomycin susceptibility in vancomycin-resistant Enterococcus faecium vanA ST612. It also characterizes resistance genes including vanA, aac(6')-I, msr(C), and ant(6)-Ia.
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