linB

lincosamide nucleotidyltransferase

Validation StatusSupported

Overview

Validation Method: expression in E. coli and S. aureus, inactivation of lincosamides
Drug Classes: Lincomycin, Clindamycin, Erythromycin
Organisms: Enterococcus faecium HM1025, Escherichia coli, Staphylococcus aureus, Enterococcus faecium, Streptococcus uberis, Streptococcus agalactiae
Geographic Location: China, Europe|North America|Asia, France, Hungary
Papers: 5
Databases: Reslit

Papers5

A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.

PMID 10103201 · 1999

The study identifies a novel resistance gene, linB, which confers resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025. The gene encodes a lincosamide nucleotidyltransferase that inactivates lincomycin and clindamycin.

Gene Information

Gene Name: linB
Allele: linB
Encodes: lincosamide nucleotidyltransferase
Source Database: Reslit
Confers Resistance To: LincomycinClindamycin
Organisms Tested In: • Enterococcus faecium HM1025
• Escherichia coli
• Staphylococcus aureus
Validation Method: expression in E. coli and S. aureus, inactivation of lincosamides
Sequence Accession: AF110130

Antimicrobial Resistance Mechanisms and Molecular Detection Techniques

PMID 11585788 · 2023

The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.

Gene Information

Gene Name: linB
Allele: linB
Encodes: lincomycin nucleotidyltransferase
Source Database: Reslit
Confers Resistance To: Lincomycin
Organisms Tested In: • Enterococcus faecium
Geographic Location: Europe|North America|Asia
Validation Method: PCR and sequencing

Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.

PMID 20952646 · 2010

The study identified various AMR genes including erm(B), linB, lnuD, tet(M), tet(S), and tet(O) associated with resistance to macrolides, lincosamides, and tetracyclines in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.

Gene Information

Gene Name: linB
Allele: linB
Encodes: lincosamide nucleotidyltransferase
Source Database: Reslit
Confers Resistance To: Lincomycin
Organisms Tested In: • Streptococcus uberis
Geographic Location: France
Validation Method: PCR

High prevalence of group B streptococcus ST17 hypervirulent clone among non-pregnant patients from a Hungarian venereology clinic.

PMID 31779587 · 2019

The study identified high levels of macrolide and clindamycin resistance in Streptococcus agalactiae isolates from non-pregnant patients in Hungary, with the presence of ermB, ermTR, mef, and linB genes contributing to resistance. The ST-17 hypervirulent clone was prevalent among the isolates.

Gene Information

Gene Name: linB
Allele: linB
Encodes: macrolide resistance
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Streptococcus agalactiae
Geographic Location: Hungary
Validation Method: PCR detection of resistance genes
Sequence Accession: MG675237

Emerging Fatal Ib/CC12 Hypervirulent Multiresistant Streptococcus agalactiae in Young Infants With Bloodstream Infection in China.

PMID 34975795 · 2021

The study identifies multiple antibiotic resistance genes in Ib/CC12 Streptococcus agalactiae strains, including genes conferring resistance to macrolides, clindamycin, aminoglycosides, tetracycline, and other antibiotics.

Gene Information

Gene Name: linB
Allele: linB
Encodes: Hypothetical protein
Source Database: Reslit
Confers Resistance To: Clindamycin
Organisms Tested In: • Streptococcus agalactiae
Geographic Location: China
Validation Method: genome analysis
Sequence Accession: JAIOKR000000000|JAIOKS000000000|JAIOKT000000000|JAIOKU000000000|JAIONE000000000|JAIONF000000000

Browse AMR Genes

linB

Gene Information

Gene Information

Gene Information

Gene Information

Gene Information