linb
lincosamide nucleotidyltransferase
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to linb
AMR Rules
Browse AMR rules for linb
Curation StatusNot Validated
Overview
- Drug Classes
- lincomycin, clindamycin
- Organisms
- Enterococcus faecium HM1025, Escherichia coli, Staphylococcus aureus +1 more
- Papers
- 2
Papers2
1
A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.
PMID 10103201 · 1999The study identifies a novel resistance gene, linB, which confers resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025. The gene encodes a lincosamide nucleotidyltransferase that inactivates lincomycin and clindamycin.
Gene Information
- Gene Name
- linb
- Allele
- linB
- Encodes
- lincosamide nucleotidyltransferase
- Validation Method
- expression in E. coli and S. aureus, inactivation of lincosamides
Confers Resistance To
lincomycinclindamycin
Organisms Tested In
• Enterococcus faecium HM1025
• Escherichia coli
• Staphylococcus aureus
2
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- linb
- Allele
- linB
- Encodes
- lincomycin nucleotidyltransferase
- Validation Method
- PCR and sequencing
Confers Resistance To
lincomycin
Organisms Tested In
• Enterococcus faecium
Isolation Details
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