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ResLit

lmrC

ABC-F type ribosomal protection protein LmrC

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to lmrC

AMR Rules

Browse AMR rules for lmrC

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target protection
Validation Method: antimicrobial susceptibility testing
Drug Classes: FOSFOMYCIN, Erythromycin, Clindamycin, Lincomycin, Lincosamide
Organisms: Streptomyces lincolnensis, Streptococcus equi subsp. equi, Nocardia cyriacigeorgica
Geographic Location: China
Alleles: 2
Papers: 4
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
LmrC	Card DatabaseReference Gene CatalogReslit	5	FOSFOMYCIN, Erythromycin +3	Streptomyces lincolnensis +2	China	2006, 2023, 2025	EU124663.1

Papers4

Ubiquity and diversity of multidrug resistance genes in Lactococcus lactis strains isolated between 1936 and 1995.

PMID 16958846 · 2006

Gene Information

Gene Name: lmrC
Allele: LmrC
Encodes: ABC-F type ribosomal protection protein LmrC
Source Database: Reference Gene Catalog
Mechanism: antibiotic target protection
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Streptomyces lincolnensis
Sequence Accession: EU124663.1
Protein Accession: ABX00624.1
Notes: ARO:3002881

Ubiquity and diversity of multidrug resistance genes in Lactococcus lactis strains isolated between 1936 and 1995.

PMID 16958846 · 2006

Gene Information

Gene Name: lmrC
Allele: LmrC
Encodes: ABC-F type ribosomal protection protein LmrC
Source Database: Card Database
Mechanism: antibiotic target protection
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Streptomyces lincolnensis
Sequence Accession: EU124663.1
Protein Accession: ABX00624.1
Notes: ARO:3002881

Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.

PMID 38029076 · 2023

The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.

Gene Information

Gene Name: lmrC
Allele: LmrC
Encodes: multidrug resistance protein
Source Database: Reslit
Mechanism: macrolide, lincosamide, streptogramin resistance
Confers Resistance To: ErythromycinClindamycinLincomycin
Organisms Tested In: • Streptococcus equi subsp. equi
Geographic Location: China
Validation Method: antimicrobial susceptibility testing
Sequence Accession: CP133957|CP133955|CP133956

Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica.

PMID 40188140 · 2025

The study identified several antimicrobial resistance genes in Nocardia cyriacigeorgica, including VanSO and VanRO for vancomycin resistance, erm(O)-Irm, srmB, and ermH for macrolide resistance, bla1 and bcl for beta-lactam resistance, CTX-M and KPC for cephalosporin and carbapenem resistance, tetA(58) and tetB(58) for tetracycline resistance, folC and folP for sulfonamide resistance, rbpA and rpoB2 for rifamycin resistance, murA and AbaF for fosfomycin resistance, cmlR for chloramphenicol resistance, and VatF and VatE for streptogramin resistance.

Gene Information

Gene Name: lmrC
Allele: LmrC
Encodes: ABC-F subfamily protein that confers resistance to lincosamides
Source Database: Reslit
Mechanism: Efflux pump
Confers Resistance To: Lincosamide
Organisms Tested In: • Nocardia cyriacigeorgica
Geographic Location: China
Validation Method: BLASTP against CARD
Sequence Accession: SAMN46383565|GCA_027924465.1|GCA_010858005.1|SAMN46383563|GCA_015477225.1|GCA_015477975.1|GCA_000284035.1|GCA_015477645.1|GCA_029868645.1|GCA_027924275.1|GCA_010868115.1|GCA_010868145.1|GCA_010868155.1|GCA_029868385.1|GCA_005863245.1|GCA_005863295.1|GCA_015478165.1|GCA_015478435.1|GCA_015478155.1|SAMN46383564|GCA_015478075.1|GCA_010858045.1|GCA_015477995.1|SAMN46383566|GCA_015477865.1|GCA_029868465.1|GCA_900683635.1|GCA_015478375.1|GCA_015477145.1|GCA_015477345.1|GCA_015477725.1|GCA_015478465.1|SAMN46383567|GCA_015476895.1|GCA_015476905.1|GCA_015476925.1|GCA_015477945.1|GCA_015478055.1|GCA_029868825.1|GCA_002933455.1|GCA_029868925.1|GCA_029868665.1|GCA_029868765.1|GCA_029868805.1|GCA_029869825.1|GCA_029868685.1|GCA_029868705.1|GCA_002949635.1|GCA_029868265.1|GCA_029867605.1|GCA_029869675.1|GCA_029869725.1|GCA_029867685.1|GCA_029867665.1|GCA_029867565.1|GCA_000308555.1|GCA_005863225.1|GCA_029867425.1|GCA_029868785.1|GCA_029868005.1|PRJNA1214743

Genomic and phenotypic characterization of antimicrobial resistance in clinical Nocardia species isolates.

PMID 41050760 · 2025

Gene Information

Gene Name: lmrC
Allele: LmrC
Encodes: lincosamide resistance
Source Database: Reslit
Confers Resistance To: Lincomycin
Organisms Tested In: • Nocardia cyriacigeorgica
Validation Method: genomic analysis and phenotypic correlation

PMID N/A

Gene Information

Gene Name: lmrC
Allele: lmrC
Encodes: Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Source Database: Card Database
Mechanism: antibiotic target protection
Organisms Tested In: • Streptomyces lincolnensis
Sequence Accession: EU124663.1
Protein Accession: ABX00624.1
Notes: ARO:3002881