lnu(AN2)

lincosamide nucleotidyltransferase Lnu(AN2)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: putatively related to lincosamides resistance
Validation Method: ABRicate screening with ResFinder, NCBI, and CARD databases
Drug Classes: LINCOSAMIDE, Clindamycin, Lincosamide
Organisms: Bacteroides fragilis, Campylobacter coli, Streptococcus pneumoniae
Geographic Location: Australia, Denmark, Spain, global
Papers: 5
Databases: Reference Gene CatalogReslit

Papers5

Characterization of a Bacteroides mobilizable transposon, NBU2, which carries a functional lincomycin resistance gene.

PMID 10852890 · 2000

Gene Information

Gene Name: lnu(AN2)
Allele: Lnu(AN2)
Encodes: lincosamide nucleotidyltransferase Lnu(AN2)
Source Database: Reference Gene Catalog
Confers Resistance To: LINCOSAMIDE
Organisms Tested In: • Bacteroides fragilis
Sequence Accession: AF251288.1
Protein Accession: AAF74724.1

Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.

PMID 31697231 · 2019

The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.

Gene Information

Gene Name: lnu(AN2)
Allele: Lnu(AN2)
Encodes: lincomycin nucleotidyl transferase
Source Database: Reslit
Confers Resistance To: Clindamycin
Organisms Tested In: • Bacteroides fragilis
Geographic Location: Denmark
Validation Method: ABRicate screening with ResFinder, NCBI, and CARD databases
Sequence Accession: PRJNA525024|PRJNA244942|PRJNA244943|PRJNA244944|PRJNA253771|PRJNA254401|PRJNA254455

Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.

PMID 33042043 · 2020

The study identified 15 acquired genes associated with resistance to five distinct antibiotic classes in Campylobacter spp., including novel beta-lactamase genes blaOXA-493 and blaOXA-576, and characterized mutations in gyrA, rpsL, and 23S rRNA that confer resistance to fluoroquinolones, streptomycin, and macrolides, respectively.

Gene Information

Gene Name: lnu(AN2)
Allele: Lnu(AN2)
Encodes: O-nucleotidyltransferase
Source Database: Reslit
Mechanism: putatively related to lincosamides resistance
Confers Resistance To: Lincosamide
Organisms Tested In: • Campylobacter coli
Geographic Location: global
Validation Method: in silico analysis

Genomic Background and Phylogeny of cfiA-Positive Bacteroides fragilis Strains Resistant to Meropenem-EDTA.

PMID 33809460 · 2021

The study identifies two new metallo-beta-lactamase genes, cfiA14b and cfiA28, in Bacteroides fragilis strains resistant to meropenem-EDTA. Additionally, various other AMR genes such as aadS, aac(3'), ermF, lnu(AN2), vatA, mef(En2), tetX, tetQ, cat, bexA, bexB, qacE, cusR, mexAB-oprM, mexJK-oprM, mexXY-oprM, acrEF-tolC, and mdtEF-tolC were characterized.

Gene Information

Gene Name: lnu(AN2)
Allele: Lnu(AN2)
Encodes: lincosamide nucleotidyltransferase
Source Database: Reslit
Confers Resistance To: Lincosamide
Organisms Tested In: • Bacteroides fragilis
Geographic Location: Spain
Validation Method: detection in strain CNM20180471
Sequence Accession: JACLQC000000000|JADDIJ000000000

Diverse Bacterial Resistance Genes Detected in Fecal Samples From Clinically Healthy Women and Infants in Australia-A Descriptive Pilot Study.

PMID 34603219 · 2021

The study identified 64 unique antimicrobial resistance genes (ARGs) in fecal samples from clinically healthy individuals in Australia, with a focus on tetracycline, beta-lactam, and MLS B resistance genes.

Gene Information

Gene Name: lnu(AN2)
Allele: Lnu(AN2)
Encodes: Lincosamide nucleotidyltransferase
Source Database: Reslit
Confers Resistance To: Lincosamide
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: Australia
Validation Method: Metagenomic analysis
Sequence Accession: PRJEB36405

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lnu(AN2)

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