Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
lincosamide nucleotidyltransferase Lnu(D)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Lnu(D) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | LINCOMYCIN, LINCOSAMIDE +4 | Streptococcus uberis |
| Sub-Saharan Africa|Middle East & North Africa|South Asia|Europe |
| 2008, 2015, 2018, 2025 |
| EF452177.1 |
| ABR14060.1 |
| lnu(D) | ResFinder Database | 1 | LINCOMYCIN | Streptococcus uberis | - | 2008 | EF452177 | - |
| lnuD | Card DatabaseReslit | 5 | Lincomycin, Lincosamide +6 | Streptococcus uberis | France, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Australia, Australia|Czech Republic|Italy|New Zealand | 2010, 2018, 2021, 2025 | NC_008721|NC_004585|NC_013644|NC_012753|NC_012756|NC_028700|NC_004586 | ABR14060.1 |
Lincomycin resistance gene lnu(D) in Streptococcus uberis.
Lincomycin resistance gene lnu(D) in Streptococcus uberis.
Lincomycin resistance gene lnu(D) in Streptococcus uberis.
Lincomycin resistance gene lnu(D) in Streptococcus uberis.
The study identifies a new lincosamide resistance gene, lnu(D), which confers resistance to lincomycin and clindamycin in Streptococcus uberis. The gene was cloned and functionally validated in E. coli.
Lincomycin resistance gene lnu(D) in Streptococcus uberis.
Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
The study identified various AMR genes including erm(B), linB, lnuD, tet(M), tet(S), and tet(O) associated with resistance to macrolides, lincosamides, and tetracyclines in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D).
The study characterized the lncosamide nucleotidylyltransferases lnu(A) and lnu(D), demonstrating their ability to inactivate lincosamide antibiotics through nucleotidylylation. Structural analysis revealed distinct C-terminal domains that contribute to substrate specificity.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens.
The study characterizes various AMR genes involved in resistance to multiple antibiotics, including beta-lactams, aminoglycosides, macrolides, tetracyclines, and others, in different bacterial species such as Staphylococcus aureus, Enterococcus faecium, and Serratia marcescens.
Sequence characterisation and novel insights into bovine mastitis-associated Streptococcus uberis in dairy herds.
The study identified antibiotic resistance genes in Streptococcus uberis isolates, including a multidrug resistance cluster consisting of mel/mef(A), mrsE, vatD, and lnuD, which confer resistance to various antibiotics such as lincosamides, macrolides, oxazolidinones, phenicols, pleuromutilins, streptogramins, and tetracyclines.
Global analysis of the genomic diversity, antimicrobial resistance and potential vaccine candidates carried by the major global bovine pathogen Streptococcus uberis.
The study identified 35% of S. uberis isolates carrying acquired antimicrobial resistance genes, including ant(6)-la, aph(3')-lla, tetL, tetM, tetS, lnuC, and lnuD. Additionally, mutations in penicillin-binding proteins pbp2b (N366I, T402I) and pbp2x (E381K, Q554E, V590A, G600E) were associated with reduced penicillin susceptibility.
Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes.
The study identifies several AMR genes, including aph(6)-id_2, mef(c), mef(b), mph(e), mph(g), msr(d), lnu(b), lnu(d), aadA, ant(6)-Ia, blaCTX-M, blaTEM, blaSHV, blaOXA, qnrS1, mcr-1, and vanA, which are associated with resistance to various antibiotics such as aminoglycosides, macrolides, lincosamides, beta-lactams, fluoroquinolones, polymyxins, and glycopeptides.
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