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ResLit

lnu(E)

lincosamide nucleotidyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to lnu(E)

AMR Rules

Browse AMR rules for lnu(E)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: de novo synthesis and functional confirmation in S. aureus
Drug Classes: Lincomycin, LINCOMYCIN, LINCOSAMIDE
Organisms: Streptococcus suis, Staphylococcus aureus, synthetic construct, Enterococcus faecalis
Geographic Location: global
Alleles: 3
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Lnu(E)	Card DatabaseReference Gene CatalogReslit	4	Lincomycin, LINCOSAMIDE	Streptococcus suis +2	global	2014, 2023	KF287643

Papers2

Identification of the novel lincosamide resistance gene lnu(E) truncated by ISEnfa5-cfr-ISEnfa5 insertion in Streptococcus suis: de novo synthesis and confirmation of functional activity in Staphylococcus aureus.

PMID 24366733 · 2014

The study identifies a novel lincosamide resistance gene, lnu(E), which was truncated by an insertion of an IS Enfa5-cfr-IS Enfa5 segment in Streptococcus suis. The gene was synthetically reconstructed and confirmed to confer resistance to lincomycin in Staphylococcus aureus.

Gene Information

Gene Name: lnu(E)
Allele: Lnu(E)
Encodes: lincosamide nucleotidyltransferase
Source Database: Reslit
Confers Resistance To: Lincomycin
Organisms Tested In: • Streptococcus suis
• Staphylococcus aureus
Validation Method: de novo synthesis and functional confirmation in S. aureus
Sequence Accession: KF287643

PMID 24366733 · 2014

Gene Information

Gene Name: lnu(E)
Allele: lnu(E)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: LINCOMYCIN
Organisms Tested In: • synthetic construct
Sequence Accession: KF287643
Notes: Lincosamide nucleotidyltransferase

Antimicrobial Resistance in Staphylococci of Animal Origin

PMID 29992898 · 2023

The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.

Gene Information

Gene Name: lnu(E)
Allele: Lnu(E)
Encodes: lincosamide nucleotidyltransferase
Source Database: Reslit
Confers Resistance To: Lincomycin
Organisms Tested In: • Streptococcus suis
Geographic Location: global
Validation Method: experimental evidence

PMID N/A

Gene Information

Gene Name: lnu(E)
Allele: Lnu(E)
Encodes: lincosamide nucleotidyltransferase Lnu(E)
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: LINCOSAMIDE
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: ABEWJH010000071.1
Protein Accession: EIV0112638.1
Notes: ARO:3003762

PMID N/A

Gene Information

Gene Name: lnu(E)
Allele: Lnu(E)
Encodes: lincosamide nucleotidyltransferase Lnu(E)
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: LINCOSAMIDE
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: ABEWJH010000071.1
Protein Accession: EIV0112638.1
Notes: ARO:3003762

PMID N/A

Gene Information

Gene Name: lnu(E)
Allele: lnuE
Encodes: lincosamide nucleotidyltransferase (LNU)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • synthetic construct
Sequence Accession: KF287643.1
Protein Accession: AGT57825.1
Notes: ARO:3003762