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ResLit

lpxA

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to lpxA

AMR Rules

Browse AMR rules for lpxA

Overview

Drug Classes: Colistin, COLISTIN, Polymyxin, Polymyxin b
Organisms: Acinetobacter baumannii, Acinetobacter junii, Chryseobacterium indologenes, Chryseobacterium oranimense
Papers: 14
Mutations: 17

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q72K	-	single resistance variant, acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase LpxA	Acinetobacter baumannii	COLISTIN	Card DatabaseReference Gene Catalog	Confirmed
R123K	-	-	-	Colistin	Reslit	Candidate
G68D	GGT->GAT	single resistance variant, acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase LpxA

Papers14

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production.

PMID 20855724 · 2010

LpxA; CARD accession: CARD:3003573

lpxA

Mutation Information

lpxA: p.Q72K lpxA: p.G68D lpxA: p.H159D lpxA: p.D233Ter

Protein Change: Q72K, G68D, H159D, D233Ter
Organisms: Acinetobacter baumannii
Confers Resistance To: COLISTIN
Effect on Function: single resistance variant; acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase LpxA
Source Database: Card DatabaseReference Gene Catalog

Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing.

PMID 22914622 · 2012

Mutation in lpxA associated with colistin resistance.

Mutation Information

lpxA: p.R123K

Protein Change: R123K
Confers Resistance To: Colistin
Source Database: Reslit

Epidemiological and genomic characteristics of Acinetobacter baumannii from different infection sites using comparative genomics.

PMID 34247587 · 2021

The mutation H131Y in lpxA was associated with polymyxin resistance.

Mutation Information

lpxA: p.H131Y

Protein Change: H131Y
Confers Resistance To: Polymyxin
Source Database: Reslit

In vitro pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against Acinetobacter baumannii.

PMID 40135861 · 2025

Mutation Information

lpxA: p.S224P

Protein Change: S224P
Organisms: Acinetobacter baumannii
Confers Resistance To: Polymyxin b
Source Database: Reslit

Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.

PMID 35002996 · 2021

Mutation in lpxA gene associated with colistin resistance

Mutation Information

lpxA: p.Y131H

Protein Change: Y131H
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

Emergence of Colistin-Resistant Acinetobacter junii in China.

PMID 36551350 · 2022

Mutation Information

lpxA: p.I107F lpxA: p.H131Y

Protein Change: I107F, H131Y
Organisms: Acinetobacter junii
Confers Resistance To: Colistin
Source Database: Reslit

The molecular characterization of colistin-resistant isolates of Acinetobacter baumannii from patients at intensive care units.

PMID 37124847 · 2022

Mutation Information

lpxA: p.Y292H lpxA: p.E394D

Protein Change: Y292H, E394D
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii.

PMID 37561719 · 2023

Mutation Information

lpxA: p.R304C

Protein Change: R304C
Confers Resistance To: Colistin
Source Database: Reslit

Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant Acinetobacter baumannii clinical isolates.

PMID 38214512 · 2024

Detected in colistin-resistant isolates.

Mutation Information

lpxA: p.Y131H

Protein Change: Y131H
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

The induction and identification of novel Colistin resistance mutations in Acinetobacter baumannii and their implications.

PMID 27329501 · 2016

Mutations in lpxA were observed in BAL242-Day3, BAL242-Day5, and BAL255-Day3.

Mutation Information

lpxA: p.A141T

Protein Change: A141T
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii.

PMID 29160808 · 2017

Mutation Information

lpxA: p.I76K

Protein Change: I76K
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.

PMID 35966843 · 2022

Mutation in lpxA contributes to colistin resistance.

Mutation Information

lpxA: p.G68D lpxA: c.GGA->GGA

Protein Change: G68D
Nucleotide Change: GGA->GGA
Organisms: Chryseobacterium indologenes
Confers Resistance To: Colistin
Source Database: Reslit

Colistin Resistance Onset Strategies and Genomic Mosaicism in Clinical Acinetobacter baumannii Lineages.

PMID 34832671 · 2021

Mutation Information

lpxA: p.Q140L / c.A421T lpxA: p.N5V / c.AAC->GTC

Protein Change: Q140L, N5V
Nucleotide Change: A421T, AAC->GTC
Confers Resistance To: Colistin
Source Database: Reslit

Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France.

PMID 25583710 · 2015

Mutation Information

lpxA: p.G68D / c.GGT->GAT

Protein Change: G68D
Nucleotide Change: GGT->GAT
Organisms: Chryseobacterium oranimense
Confers Resistance To: Colistin
Source Database: Reslit