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lpxC

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UniProt

Protein entries specific to lpxC

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Overview

Drug Classes: Colistin, Polymyxin, Polymyxin b, COLISTIN
Organisms: Acinetobacter baumannii, Pseudomonas aeruginosa
Papers: 16
Mutations: 25

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P30L	-	UDP-3-O-acyl-N-acetylglucosamine deacetylase LpxC, single resistance variant	Acinetobacter baumannii	ColistinCOLISTIN	Card DatabaseReference Gene CatalogReslit	Confirmed
45fs	-	-	Acinetobacter baumannii	Colistin	Reslit	Candidate
285fs

Papers16

1

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

PMID 20855724 · 2010

Mutations in lpxC lead to complete loss of LPS production and colistin resistance.

lpxC

LpxC; CARD accession: CARD:3003574

Mutation Information

lpxC: p.P30L lpxC: p.45fs lpxC: p.285fs

Protein Change: P30L, 45fs, 285fs
Organisms: Acinetobacter baumannii
Confers Resistance To: ColistinCOLISTIN
Effect on Function: UDP-3-O-acyl-N-acetylglucosamine deacetylase LpxC; single resistance variant
Source Database: ReslitReference Gene CatalogCard Database

2

Rapid and Consistent Evolution of Colistin Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa during Morbidostat Culture.

PMID 28630206 · 2017

Observed in PA83 cultures

Mutation Information

lpxC: p.A107T lpxC: p.V222A

Protein Change: A107T, V222A
Organisms: Pseudomonas aeruginosa
Confers Resistance To: Colistin
Source Database: Reslit

3

Epidemiological and genomic characteristics of Acinetobacter baumannii from different infection sites using comparative genomics.

PMID 34247587 · 2021

Mutations in lpxC were associated with polymyxin resistance.

Mutation Information

lpxC: p.M115I lpxC: p.D159N lpxC: p.H149Y lpxC: p.D287N

Protein Change: M115I, D159N, H149Y, D287N
Confers Resistance To: Polymyxin
Source Database: Reslit

4

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions.

PMID 27694971 · 2016

Mutation Information

lpxC: p.A54V

Protein Change: A54V
Organisms: Pseudomonas aeruginosa
Confers Resistance To: Colistin
Source Database: Reslit

5

Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.

PMID 35002996 · 2021

Mutations in lpxC gene associated with colistin resistance

Mutation Information

lpxC: p.C120R lpxC: p.N287D

Protein Change: C120R, N287D
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

6

Prevalence and Genetic Characterization of Carbapenem- and Polymyxin-Resistant Acinetobacter baumannii Isolated from a Tertiary Hospital in Terengganu, Malaysia.

PMID 25006521 · 2014

Mutation Information

lpxC: p.K141R lpxC: p.S158R

Protein Change: K141R, S158R
Organisms: Acinetobacter baumannii
Confers Resistance To: Polymyxin b
Source Database: Reslit

7

Bacteremia by colistin-resistant Acinetobacter baumannii isolate: a case report.

PMID 31064407 · 2019

Mutations in lpxC may contribute to colistin resistance

Mutation Information

lpxC: p.H31P

Protein Change: H31P
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

8

Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology.

PMID 36978383 · 2023

Mutations in lpxC lead to complete loss of LPS, resulting in colistin resistance.

Mutation Information

lpxC: p.N287D lpxC: p.S186R

Protein Change: N287D, S186R
Confers Resistance To: Colistin
Source Database: Reslit

9

The molecular characterization of colistin-resistant isolates of Acinetobacter baumannii from patients at intensive care units.

PMID 37124847 · 2022

Mutation Information

lpxC: p.F165L lpxC: p.C120R

Protein Change: F165L, C120R
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

10

Acinetobacter baumannii Global Clone-Specific Resistomes Explored in Clinical Isolates Recovered from Egypt.

PMID 37508245 · 2023

Mutation Information

lpxC: p.N268Y

Protein Change: N268Y
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

11

Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii.

PMID 37561719 · 2023

Mutation Information

lpxC: p.K374E

Protein Change: K374E
Confers Resistance To: Colistin
Source Database: Reslit

12

Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant Acinetobacter baumannii clinical isolates.

PMID 38214512 · 2024

Detected in colistin-resistant isolates.

Mutation Information

lpxC: p.N287D lpxC: p.C120R lpxC: p.F230Y lpxC: p.P148S

Protein Change: N287D, C120R, F230Y, P148S
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Effect on Function: stabilizing; destabilizing
Source Database: Reslit

13

Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism.

PMID 26779129 · 2015

Mutations in lpxC gene contribute to polymyxin resistance in AC30.