Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
lincomycin resistance ATP-binding cassette transporter
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| lsa(E) | Card DatabaseResFinder Database | 2 | CLINDAMYCIN, LINCOMYCIN +4 | Staphylococcus aureus +1 | - | 2013 | JX560992 | AAL05553.1 |
| Lsa(E) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 31 | Clindamycin, Pleuromutilin +24 | Staphylococcus chromogenes +16 | Brazil, Europe, global, Portugal, Sweden|Italy|Denmark, Germany, China, Asia|Europe|Americas|China|Taiwan, South Korea, Israel, Minnesota, Chiang Mai province, Northern Thailand|Thailand, Taiwan, Ghana, Spain, China|UK|Canada|Thailand|Netherlands|USA|Denmark|Spain|other nations, Thailand | 2014, 2017, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | HG970733 | AAL05553.1 |
| lsaE | Reslit | 20 | Tiamulin, Retapamulin +12 | Lactobacillus +21 | Europe, Poland, Eastern China, United States, Italy, China, Canada|United Kingdom|Alberta, Belgium, Latvia, Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy, Europe|Belgium|France|Germany|Netherlands|United Kingdom, Poland|Australia | 2017, 2018, 2020, 2021, 2022, 2023, 2024, 2025 | AM946016|CP031377|CP031378|CP030017|CP030022|CP031379|CP030020|CP030021|CP030023|CP030015|CP030016|CP030030|CP030010|CP030011|CP030012|CP030013|CP030014|CP012345|CP012346|CP012347|CP012348|CP012349|CP012350|CP012351|CP012352|CP012353 | - |
| lsa(E ) | Reslit | 1 | Lincosamide, Streptogramin a +1 | Enterococcus faecium +2 | Portugal | 2025 | KT862784|MH746818|CP161870|CP161865|CP161871|CP161866 | - |
Detection and new genetic environment of the pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in methicillin-resistant Staphylococcus aureus of swine origin.
Characterization of methicillin-resistant coagulase-negative staphylococci in milk from cows with mastitis in Brazil.
The study identified methicillin-resistant coagulase-negative staphylococci (MRCoNS) in milk from cows with mastitis in Brazil, highlighting the presence of various antimicrobial resistance genes including mecA, tet(K), str, ant(4')-I, aac(6')-aph(2"), lnu(B), lsa(E), and a modified erm(C) gene with an 89-bp deletion.
Detection and Genetic Environment of Pleuromutilin-Lincosamide-Streptogramin A Resistance Genes in Staphylococci Isolated from Pets.
The study identifies sal(A), vga(A) LC, and lsa(E) as PLS A resistance genes in staphylococci from pets, highlighting their presence in new species and genetic contexts.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Characterization of a new transferable MDR plasmid carrying the pbp5 gene from a clade B commensal Enterococcus faecium.
Low Prevalence of Gram-Positive Isolates Showing Elevated Lefamulin MIC Results during the SENTRY Surveillance Program for 2015-2016 and Characterization of Resistance Mechanisms.
Next-Generation Sequencing and MALDI Mass Spectrometry in the Study of Multiresistant Processed Meat Vancomycin-Resistant Enterococci (VRE).
The study identified multiple AMR genes in vancomycin-resistant enterococci (VRE) isolated from processed meat, including vanA, vanC1, erm(B), aac(6')-Ii, aadE, ant(9)-Ia, lsa(E), msr(C), lnu(B), tet(M)+tet(L), dfrG, dfrK, adeC, and efmA, which confer resistance to various antibiotics such as vancomycin, erythromycin, tetracycline, aminoglycosides, and trimethoprim.
Prevalence and molecular characterization of methicillin-resistant Staphylococcus aureus with mupirocin, fusidic acid and/or retapamulin resistance.
The study identified mupA as the primary gene responsible for high-level mupirocin resistance, and mutations in ileS (N213D and V588F) for low-level mupirocin resistance. Additionally, lsaE was found to contribute to retapamulin resistance.
Comparative genome analysis of Erysipelothrix rhusiopathiae isolated from domestic pigs and wild boars suggests host adaptation and selective pressure from the use of antibiotics.
The study identified tetracycline resistance gene tet(M), and combinations of lsa(E) and lnu(B) conferring resistance to lincosamides, pleuromutilins, and streptogramin A in Erysipelothrix rhusiopathiae isolates from pigs, but not in wild boar isolates.
Evidence for the Dissemination to Humans of Methicillin-Resistant Staphylococcus aureus ST398 through the Pork Production Chain: A Study in a Portuguese Slaughterhouse.
The study identified multiple antimicrobial resistance genes in MRSA ST398 isolates from a Portuguese slaughterhouse, highlighting the dissemination of these resistant strains through the pork production chain and their potential to colonize humans.
Antimicrobial resistance and virulence factors in livestock-associated MRSA from German dairy farms
The study identified various antimicrobial resistance genes in livestock-associated MRSA from German dairy farms, including mecA, fexA, tet(K), tet(M), vga(A), vga(E), dfrG, dfrK, aac(6')Ie-aph(2")Ia, str, spc, lsa(E), and erm(A). These genes conferred resistance to beta-lactams, chloramphenicol, tetracyclines, pleuromutilins, trimethoprim, aminoglycosides, streptomycin, spectinomycin, macrolides, lincosamides, and streptogramin B.
SWINE VIRULENCE ASSESSMENT
This study analyzed the virulence and genomic characteristics of nine United States Streptococcus suis isolates, identifying genomic attributes associated with swine-virulent phenotypes. However, no specific AMR genes or mutations were experimentally validated in this paper.
A Conjugative MDR pMG1-Like Plasmid Carrying the lsa(E) Gene of Enterococcus faecium With Potential Transmission to Staphylococcus aureus.
The study identified the lsa(E) gene, which confers resistance to pleuromutilins, lincosamides, and streptogramin A, on a conjugative MDR plasmid pN7435-R3645. This plasmid was successfully transferred from Enterococcus faecium to Staphylococcus aureus in vitro, highlighting its potential role in the spread of antimicrobial resistance.
Molecular Evolution and Adaptation of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) Sequence Type 9.
The study identifies multiple AMR genes and mutations in ST9 S. aureus, including mecA, blaZ, lnu(B), lsa(E), erm(C), fexA, tet(L), dfrG, vwb, and the MDR ST9 element, highlighting their role in multidrug resistance and host adaptation.
Molecular Characteristics of IS1216 Carrying Multidrug Resistance Gene Cluster in Serotype III/Sequence Type 19 Group B Streptococcus.
The study identified multidrug resistance gene clusters in non-srr1/2 serotype III Group B Streptococcus (GBS) isolates, including lnu(B), lsa(E), aadK, aadE, and aac(3)-IV, which confer resistance to lincosamides, streptomycin, and aminoglycosides.
Whole Genome Analysis of Three Multi-Drug Resistant Listeria innocua and Genomic Insights Into Their Relatedness With Resistant Listeria monocytogenes.
The study identified multiple AMR genes in three multi-drug resistant L. innocua isolates, including tet(M), optrA, fexA, dfrG, lnu(B), lsa(E), ant(6)-Ia, erm(B), aph(3')-IIIa, catA8, lnu(A), msr(D), and mef(A). These genes confer resistance to various antibiotics such as tetracycline, oxazolidinones, fluoroquinolones, trimethoprim, lincomycin, macrolides, aminoglycosides, and chloramphenicol.
Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 8: Pleuromutilins: tiamulin and valnemulin.
The paper discusses resistance mechanisms to pleuromutilins, including tiamulin and valnemulin, highlighting chromosomal mutations in 23S rRNA and rplC genes, as well as transferable resistance genes like vga(A), cfr, and lsa(E).
Invasive Multidrug-Resistant emm93.0 Streptococcus pyogenes Strain Harboring a Novel Genomic Island, Israel, 2017-2019.
The study identified multidrug resistance in an emm93.0 Streptococcus pyogenes strain in Israel, including resistance to clindamycin, tetracycline, and trimethoprim/sulfamethoxazole. A novel genomic island containing resistance genes lsa(E), lnu(B), ant(6)-Ia, and aph(3')-IIIa was discovered.
New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019.
The study identified several AMR genes in Streptococcus suis isolates from diseased pigs in Italy, including ermb, tet(O), aac6-aph2, ant6-ia, aph3-iiia, spw, tet(40), tet(W), tet(O/W/32/O), tet(W/N/N), erm(47), lnuB, lsaE, and optrA, which confer resistance to various antibiotics such as erythromycin, tetracycline, gentamicin, lincomycin, and linezolid.
Characterization of Erysipelothrix rhusiopathiae Isolates from Diseased Pigs in 15 Chinese Provinces from 2012 to 2018.
The study identified the macrolide resistance gene erm(A)-like, the tetracycline resistance gene tet(M), and the streptogramin B resistance gene lsa(E) in Erysipelothrix rhusiopathiae isolates. Additionally, mutations in gyrA (86T-I) and parC (81S-I) were linked to quinolone resistance.
Emerging Fatal Ib/CC12 Hypervirulent Multiresistant Streptococcus agalactiae in Young Infants With Bloodstream Infection in China.
The study identifies multiple antibiotic resistance genes in Ib/CC12 Streptococcus agalactiae strains, including genes conferring resistance to macrolides, clindamycin, aminoglycosides, tetracycline, and other antibiotics.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
Antimicrobial resistance determinants in silage.
The study identified 16 antimicrobial resistance genes (ARGs) in silage samples, highlighting their potential to spread through the food chain and contribute to antimicrobial resistance.
Bacillus licheniformis-fermented products and enramycin differentially modulate microbiota and antibiotic resistome in the cecal digesta of broilers.
Enramycin treatment promoted the expression of bcrA, vanRI, and lsaE resistance genes while suppressing ANT(6)-Ib, vatB, and ugd. BLFPs suppressed aminoglycoside and streptogramin resistance genes but enhanced macrolide and aminocoumarin resistance genes.
Plasmid-Assisted Horizontal Transfer of a Large lsa(E)-Carrying Genomic Island in Enterococcus faecalis.
The study identifies the lsa(E) gene as part of a large chromosomal genomic island in Enterococcus faecalis strains and demonstrates that the pheromone-responsive conjugative plasmid is essential for the horizontal transfer of this genomic island.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.
The study identifies various AMR genes in Enterococcus faecium, including vanA, vanB, ermB, ermT, ermA, aad(6), aph(3')-IIIa, aac(6')-Ie-aph(2')-Ia, sat-4, tetM, tet(W/N/W), dfrG, dfrF, lnuB, optrA, and lsaE, which are associated with different habitats and geographic locations.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
The study identified 18 AMR genes in non-serotype 2 Streptococcus suis isolates from healthy pigs, including genes conferring resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, oxazolidinones, nucleosides, and phenicols.
Comparative virulence and antimicrobial resistance distribution of Streptococcus suis isolates obtained from the United States.
The study identified several antimicrobial resistance (AMR) genes in Streptococcus suis isolates from the United States, including ble, tetO, ermB, lsaE, lnuB, ant(9)-Ia, and ant(6)-Ia, which confer resistance to glycopeptides, tetracyclines, macrolide-lincosamide-streptogramin B, pleuromutilins, and aminoglycosides respectively.
Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics.
The study identifies the presence of the integrative and conjugative element ICE Sag37 in type Ib ST12 GBS isolates, which carries multiple antibiotic resistance genes such as erm(B), tet(O), aadE, aphA, ant-6, lsa(E), and lun(B), contributing to high resistance rates to erythromycin and clindamycin. Additionally, the virulence gene pezT was found in these isolates.
Plasmid-Coded Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus from Food and Livestock in Germany.
Two linezolid-resistant MRSA strains from pigs in Germany were identified, both harboring plasmid-encoded cfr genes. These strains also had additional AMR genes, indicating multidrug resistance.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Enterococcus species: insights into antimicrobial resistance and whole-genome features of isolates recovered from livestock and raw meat in Ghana.
The study identified various antimicrobial resistance genes in Enterococcus spp. isolated from livestock and raw meat in Ghana, including genes conferring resistance to erythromycin, tetracycline, chloramphenicol, and other antibiotics. Notable genes include aac(6')-Ii, aph(3')-III, ant(6)-Ia, erm(B), erm(T), msr(C), lsa(A), lsa(E), lnu(B), tet(L), tet(M), tet(S), dfrG, cat, pbp5, and ClpL.
Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022.
The study identified the prevalence of antimicrobial resistance genes in Streptococcus suis isolates from Spain, including tet(O), erm(B), lnu(B), lsa(E), tet(M), and mef(A/E). High resistance levels were observed for clindamycin, chlortetracycline, and sulfadimethoxine.
Macrolide and lincosamide resistance of Streptococcus agalactiae in pregnant women in Poland.
The study identifies the ermB, mefA, ermA, lnuB, lsaE, and tetM genes as key contributors to macrolide and lincosamide resistance in Streptococcus agalactiae isolates from pregnant women in Poland.
Streptococcus suis serotype 4: a population with the potential pathogenicity in humans and pigs.
The study identified multiple antibiotic resistance genes in Streptococcus suis serotype 4, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, oxazolidinones, and chloramphenicol. Prophages were identified as the primary vehicle for the dissemination of these resistance genes.
Integrative and Conjugative Elements and Prophage DNA as Carriers of Resistance Genes in Erysipelothrix rhusiopathiae Strains from Domestic Geese in Poland.
The study identifies the presence of resistance genes erm47 and ermB in Erysipelothrix rhusiopathiae strains from domestic geese in Poland, along with other resistance genes such as tetM, lnuB, lsaE, ant(6)-Ia, and spw. It also highlights the role of integrative and conjugative elements (ICEs) and prophage DNA in the spread of these resistance genes.
The Genetic Landscape of Antimicrobial Resistance Genes in Enterococcus cecorum Broiler Isolates.
The study identified several antimicrobial resistance genes (ARGs) in Enterococcus cecorum isolates, including ant(6)-la, ermB, lsaE, tet(M), tet(L), and vanA, which are associated with resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, and glycopeptides. Additionally, point mutations in GyrA, GyrB, ParC, and PBP2x were found to contribute to resistance against enrofloxacin and β-lactam antibiotics.
Evaluation of Antimicrobial Resistancein Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia.
The study identifies several AMR genes and mutations in Enterococcus isolates, including vanB for vancomycin resistance, lsaA, lsaE, lnuB for lincosamide resistance, tetM and tetL for tetracycline resistance, aac6'-Ii, aac6'-aph2'', aph3'-III, and ant6-Ia for aminoglycoside resistance, msrC, ermB, and ermT for macrolide resistance, and mutations in gyrA, parC, pbp5, and 23S rRNA for fluoroquinolone, penicillin, and linezolid resistance.
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.
Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe.
The study identified high frequencies of tetracycline and macrolide resistance genes, specifically tetO and ermB, in European Streptococcus suis isolates.
Antibiotic Resistance and Serotypes Distribution in Streptococcus agalactiae Bulgarian Clinical Isolates During the Years of 2021-2024.
The study identified several AMR genes associated with macrolide, lincosamide, and tetracycline resistance in Streptococcus agalactiae isolates from Bulgaria. These include ermB, ermA/TR, ermC, mefA, mefE, msrD, lnuB, lsaC, lsaE, tetM, and tetO. High resistance rates to macrolides (60.3%) and tetracyclines (89.1%) were observed.
The healthy human gut can take it all: vancomycin-variable, linezolid-resistant strains and specific bacteriocin-species interplay in Enterococcus spp.
The study identifies linezolid resistance genes optrA and poxtA in Enterococcus faecium and Enterococcus thailandicus isolates, along with a vancomycin-variable E. faecium strain. It also reveals the increasing prevalence of E. lactis in the healthy human gut and the complex interplay of bacteriocin gene profiles among Enterococcus species.
Predomination of hypervirulent ST283 and genetic diversity of levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae in Thailand.
The study identified multiple AMR genes and mutations associated with tetracycline, erythromycin, clindamycin, and levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae isolates in Thailand, highlighting the predominance of hypervirulent ST283 and the emergence of MDR-GBS.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.
The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Prophage φEr670 and Genomic Island GI_Er147 as Carriers of Resistance Genes in Erysipelothrix rhusiopathiae Strains.
The study identifies the prophage φEr670 carrying lnuB and lsaE genes, and the genomic island GI_Er147 carrying ant(6)-Ia, spw, lnu(J), and vat family genes in E. rhusiopathiae strains. These genes confer resistance to lincomycin, tetracycline, streptomycin, and spectinomycin.
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