Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
macrolide-specific efflux system
Overview
Plasmid metagenome reveals high levels of antibiotic resistance genes and mobile genetic elements in activated sludge.
The study identified several antibiotic resistance genes, including tetB(P), aadA5, ampC, macB, IS Pps1, and IS Sm2, in the plasmid metagenome of activated sludge, highlighting the presence of diverse resistance mechanisms in environmental microbial communities.
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes.
The study identified several antibiotic resistance genes in Achromobacter xylosoxidans NH44784-1996, including beta-lactamases, tetracycline efflux proteins, and macrolide resistance genes, indicating its resistance to various antibiotics.
Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance.
The study identified that the upregulation of adeB, adeJ, and macB genes is responsible for tigecycline resistance, while increased abeS expression is strongly related to amikacin resistance in multidrug-resistant Acinetobacter baumannii isolates.
The Role of the Two-Component System BaeSR in Disposing Chemicals through Regulating Transporter Systems in Acinetobacter baumannii.
The study identifies that the BaeSR two-component system regulates the expression of efflux pump genes adeA, adeB, adeI, adeJ, adeK, macA, macB, and tolC in Acinetobacter baumannii, contributing to tigecycline resistance. Deletion of baeR reduces the expression of these genes, leading to increased susceptibility to tannic acid and tigecycline.
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells.
The study identifies multiple multi-drug efflux genes, including tolC, acrA, acrB, acrD, acrF, emrA, emrB, macA, and macB, which are significantly upregulated in persister cells, contributing to reduced antibiotic accumulation and increased drug tolerance.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Differences in Gene Expression Profiles between Early and Late Isolates in Monospecies Achromobacter Biofilm.
The study identified upregulation of genes involved in antimicrobial resistance, including macrolide-specific efflux proteins MacA and MacB, RND-type multidrug resistance efflux pump genes AxyA and OprM, and a beta-lactamase gene, suggesting their role in the development of resistance in Achromobacter xylosoxidans.
Genomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.
The study identified a β-lactam resistance gene, NPS β-lactamase, and several multidrug resistance efflux pump genes, including acrB, cmeB, macA, and macB, in Pannonibacter phragmitetus strain 31801, which contributes to its resistance to various antibiotics.
Genome sequencing and analysis of the first spontaneous Nanosilver resistant bacterium Proteus mirabilis strain SCDR1.
The study identifies several AMR genes in the Nanosilver-resistant Proteus mirabilis strain SCDR1, including those conferring resistance to tetracycline, fluoroquinolones, sulfonamides, daptomycin, rifamycin, elfamycins, chloramphenicol, and amikacin.
Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae.
The study identifies the overexpression of OqxAB and MacAB efflux pumps, along with the transcriptional regulator RamA, as contributing to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae. Mutations in acrR and ramR were also found to be associated with eravacycline resistance.
Adaptation of metal and antibiotic resistant traits in novel β-Proteobacterium Achromobacter xylosoxidans BHW-15.
The study identifies multiple antibiotic resistance genes in Achromobacter xylosoxidans BHW-15, including beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps, contributing to resistance against beta-lactams, aminoglycosides, and other antibiotics.
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.
Genomic Characterization of Arcobacter butzleri Isolated From Shellfish: Novel Insight Into Antibiotic Resistance and Virulence Determinants.
The study identified several antibiotic resistance genes in Arcobacter butzleri strains isolated from shellfish, including genes conferring resistance to beta-lactams, polymyxin, chloramphenicol, tetracycline, and macrolides.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain.
The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Hospital sink traps as a potential source of the emerging multidrug-resistant pathogen Cupriavidus pauculus: characterization and draft genome sequence of strain MF1.
The study identifies 12 antibiotic resistance genes in the draft genome of Cupriavidus pauculus strain MF1, including genes encoding β-lactamases, efflux pumps, and a colistin resistance determinant. The isolate shows resistance to meropenem, amoxicillin, amikacin, gentamicin, and colistin, but susceptibility to cefotaxime, cefepime, imipenem, and ciprofloxacin.
River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.
The study identified various antibiotic resistance genes (ARGs) in river biofilms upstream and downstream of a wastewater treatment plant (WWTP), including qnrA, qnrS, mfsA, ermC, ermX, macB, mefA_10, cat, catB3, aadB, aph(3')-III, AAC(3)-Ib, bacA_1, blaPer-1, blaIMP, blaTEM, blaKPC, blaDHA, cblA, ermC, ermY, ermX, mdtL, cusF, copD, qacA, mecA, dfrF, arnA, sul1, sulA, vat(A), IS6100, ISS1N, Intl1, blaCTX-M, blaIMP, mefA_10, tolC, mdfF, acrA, dfrA27, aac(6')-IIa, vanA, intl3, and TTV. These genes were associated with resistance to various antibiotics such as fluoroquinolones, macrolides, chloramphenicol, aminoglycosides, beta-lactams, polymyxins, sulfonamides, and others. The study also found that the resistome composition varied between upstream and downstream sites, indicating the impact of WWTP effluents on the distribution of ARGs in river biofilms.
Antimicrobial Resistance and Comparative Genomic Analysis of Elizabethkingia anophelis subsp. endophytica Isolated from Raw Milk.
The study reports the first isolation of Elizabethkingia anophelis subsp. endophytica from raw milk in Russia, highlighting its multidrug resistance and the presence of various AMR genes including beta-lactamases and efflux pumps.
Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics.
The study identifies various AMR genes and mutations in soil samples, highlighting the active resistome in agricultural and natural soils. Key findings include the detection of genes like gyrA, bcrA, and macB, which confer resistance to antibiotics such as ciprofloxacin and meropenem. The research emphasizes the importance of phenotypic resistance assessment in environmental AMR monitoring.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana.
The study identified several antimicrobial resistance genes in Arcobacter butzleri isolates from poultry in Ghana, including blaOXA-464, tetM, ermB, and others, highlighting the presence of multidrug-resistant strains and the potential for horizontal and vertical transmission of resistance genes.
Sulfur: a neglected driver of the increased abundance of antibiotic resistance genes in agricultural reclaimed subsidence land located in coal mines with high phreatic water levels.
This study identifies several antibiotic resistance genes (ARGs) in reclaimed soil, highlighting the role of sulfur in increasing the abundance of ARGs. The most abundant ARGs included MacB, tetA(58), bcrA, novA, and evgS, primarily associated with efflux pump mechanisms.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.
The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.
Comparative genomics analysis of Streptococcus iniae isolated from Trachinotus ovatus: novel insight into antimicrobial resistance and virulence differentiation.
The study identifies several antibiotic resistance genes in the large inversion fragment of S.iniae BH16-24, contributing to its multidrug resistance. These genes include pbp2B, pbp1A, pbp2X, femA, gyrA, oppA, aph, dfrA, and macB, which confer resistance to beta-lactams, fluoroquinolones, aminoglycosides, trimethoprim, and macrolides.
Genomic Insights into the Adaptation and Antibiotic Resistance Mechanisms of Williamsia chitiniclastica
The study identifies several AMR genes in Wohlfahrtiimonas chitiniclastica, including macA, macB, tehB, tet(H), tet(B), ant(2″)-Ia, aac(6′)-Ib, ant(3″)-Ib, bla VEB-1, bla OXA-1, aph(3′)-Ib, sul2, strA, and dfrA1, which confer resistance to various antibiotics such as macrolides, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and trimethoprim.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
A novel pathogenic species of genus Stenotrophomonas: Stenotrophomonas pigmentata sp. nov.
The study identifies a novel pathogenic species, Stenotrophomonas pigmentata sp. nov., which exhibits resistance to multiple antibiotics, including β-lactams, carbapenems, and trimethoprim-sulfamethoxazole. Several multidrug resistance efflux pump and antibiotic resistance genes were found in its genome.
Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel.
Rumicidins are a family of proline-rich cathelicidins that inhibit bacterial protein biosynthesis by targeting the 70S ribosome. They exhibit broad-spectrum antibacterial activity and resistance mechanisms involve the SbmA transporter and MacB efflux pump.
A scientific research training programme for teaching biomedical students to identify the horizontal transfer of antibiotic resistance genes.
The study demonstrated that students could identify the antibiotic resistance integrative and conjugative element (ICE) Sma M1 from the Stenotrophomonas maltophilia MER1 genome and visualize the horizontal transfer of antibiotic resistance genes (ARGs) from S. maltophilia MER1 to E. coli 25DN through conjugation and PCR assays.
Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition.
The study identifies several phage-encoded antibiotic resistance genes (ARGs) that are enhanced under combined pesticide pollution and nitrogen deposition, including macB, tet(A), efrB, msbA, and ugd, which confer resistance to macrolides, tetracyclines, multidrug, and polymyxin.
Genomic diversity and antimicrobial resistance of Staphylococcus aureus in Saudi Arabia: a nationwide study using whole-genome sequencing.
The study identified multiple AMR genes in S. aureus isolates from Saudi Arabia, highlighting the genetic diversity and resistance patterns associated with mass gatherings. Key genes include mecA, mecR1, aacA-aphD, knt, tet(K), ermC, msrA, fcl_1, natA, macB, and dppB, which confer resistance to various antibiotics.
Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential.
The study identified 10 antibiotic resistance genes in the Actinobacillus pleuropneumoniae strain APPFJLYC01, including genes conferring resistance to multiple antibiotic classes such as β-lactams, tetracyclines, aminoglycosides, and macrolides.
No comments yet. Be the first to comment!
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research