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marA

General Bacterial Porin with reduced permeability to beta-lactams;resistance-nodulation-cell division (RND) antibiotic efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to marA

Browse AMR rules for marA

Validation StatusEstablished

Overview

Mechanism: antibiotic efflux;reduced permeability to antibiotic
Drug Classes: Fluoroquinolones, Tigecycline
Organisms: Escherichia coli str. K-12 substr. W3110, Escherichia coli, Klebsiella pneumoniae
Papers: 2
Databases: Card Database
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S127N	-	-	Escherichia coli	Fluoroquinolones	Reslit	Candidate
S103G	-	-	Escherichia coli, Klebsiella pneumoniae	Tigecycline	Reslit	Candidate

Papers2

1

Gene Information

Gene Name: marA
Allele: marA
Encodes: General Bacterial Porin with reduced permeability to beta-lactams;resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux;reduced permeability to antibiotic
Organisms Tested In: • Escherichia coli str. K-12 substr. W3110
Sequence Accession: AP009048.1
Protein Accession: BAA15221.2
Notes: ARO:3000263