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Explore antimicrobial resistance genes from the literature
mycocerosic acid synthase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| L98M | - | single resistance variant | Mycobacterium tuberculosis | Pyrazinamide | Card Database | Established |
| S213C | - | single resistance variant | Mycobacterium tuberculosis | Pyrazinamide | Card Database | Established |
| P398R | - | single resistance variant | Mycobacterium tuberculosis | Pyrazinamide |
Card Database |
| Established |
| T2005P | - | single resistance variant | Mycobacterium tuberculosis | Pyrazinamide | Card Database | Established |
| P495R | - | single resistance variant | Mycobacterium tuberculosis | Pyrazinamide | Card Database | Established |
Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis.
The study identifies two distinct mechanisms of pyrazinamide resistance: (1) missense mutations in the aspartate decarboxylase panD, which prevent pyrazinoic acid (POA)-mediated coenzyme A (CoA) depletion, and (2) loss-of-function mutations in the polyketide synthases mas and ppsA-E, which affect the synthesis of the virulence factor phthiocerol dimycocerosate (PDIM).
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