The study identifies four novel variants of mcr-3 and mcr-8 genes in a colistin-resistant Klebsiella pneumoniae isolate from Laos, highlighting the co-occurrence of these genes and their role in colistin resistance.

The study identifies mcr-8.1 as a mobile colistin resistance gene in a highly successful Klebsiella pneumoniae ST15 clone from Bangladesh, highlighting its potential for dissemination.

The paper reviews the mechanisms of colistin resistance in multidrug-resistant Gram-negative bacteria, highlighting chromosomal mutations in genes such as pmrA, pmrB, phoP, phoQ, and mgrB that alter LPS modifications and contribute to resistance.

The study reports the first occurrence of the mcr-8.1 gene in a clinical Klebsiella pneumoniae isolate from Lebanon, highlighting the emergence of plasmid-mediated colistin resistance.

A novel mcr-8.2-bearing plasmid was identified in a colistin-resistant ST395 Klebsiella pneumoniae strain of chicken origin, contributing to resistance against colistin and other antimicrobials.

The study reports the first detection of the mcr-8 gene in Kenya, which confers colistin resistance in a high-risk sequence type 15 Klebsiella pneumoniae isolate.

The study identifies mcr-8.1 in Klebsiella pneumoniae and mcr-1.1 in Escherichia coli, both contributing to colistin resistance. Chromosomal mutations in mgrB and phoP were also associated with colistin resistance.

The study identified mcr-8 in 9.83% of chicken-derived K. pneumoniae isolates, showing that mcr-8 is located on plasmids and exhibits diverse genetic contexts. The gene confers resistance to colistin by modifying lipid A with phosphoethanolamine.

The study identified mcr-1 and mcr-8 genes conferring colistin resistance, and bla OXA-181 and bla NDM-5 genes conferring carbapenem resistance in Klebsiella pneumoniae isolates from companion animals in Beijing, China.

The paper reviews intrinsic and acquired colistin resistance mechanisms in bacteria, highlighting the role of genes such as pmrA, pmrB, phoP, phoQ, mgrB, arnBCADTEF, and mcr genes in conferring resistance. It discusses the importance of these genes in the context of colistin resistance and their implications for clinical treatment.

The study identified mcr-1 and mcr-8 genes as plasmid-mediated colistin resistance mechanisms in Klebsiella pneumoniae isolates, along with chromosomal mutations in pmrB contributing to colistin resistance.

The study identified several carbapenem resistance genes, including blaKPC-2, blaNDM-1, blaNDM-4, blaNDM-5, and blaOXA-181, as well as 16S rRNA methylase genes rmtB, rmtC, and armA, and the colistin resistance gene mcr-8 in carbapenem-resistant Klebsiella pneumoniae isolates from a Vietnamese NICU.

The study identified mcr-7 and mcr-8 genes in Klebsiella pneumoniae complex isolates from slaughtered pigs in Thailand, highlighting their role in colistin resistance.

Disruption of DsbA-mediated disulfide bond formation incapacitates diverse β-lactamases and destabilizes mobile colistin resistance enzymes. Chemical inhibition of DsbA sensitizes multidrug-resistant clinical isolates to existing antibiotics.

The study identifies mcr-1.1 and mcr-8 genes as responsible for colistin resistance in Klebsiella pneumoniae and Escherichia coli strains isolated from clinical and environmental sources in China.

The study reports the emergence of an ST1326 multidrug-resistant Klebsiella pneumoniae strain co-harboring mcr-8.2, ESBL genes, and the tmexCD1-toprJ1 efflux pump gene cluster, highlighting the significance of these resistance mechanisms in clinical settings.

The study reports the emergence of the mcr-8.2 gene in a multidrug-resistant Enterobacter cloacae isolate from a patient in China, highlighting its role in colistin resistance.

The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.

The study identifies an NDM-5-producing ST656 Klebsiella pneumoniae isolate that co-harbors the plasmid-encoded mcr-8.2 gene and chromosomal mutations contributing to colistin and tigecycline resistance.

The study identified six mcr variants (mcr-1.1, mcr-8.1, mcr-8.2, mcr-9.1, mcr-9.2, and mcr-10.1) in 20 genomes of Klebsiella isolates, with mcr-10.1 being susceptible to colistin in three species of Klebsiella. The study also characterized the genetic contexts of these mcr variants and their association with various plasmid types.

The study identified six mcr variants (mcr-1.1, mcr-8.1, mcr-8.2, mcr-9.1, mcr-9.2, and mcr-10.1) in 20 genomes of Klebsiella isolates, with mcr-10.1 being susceptible to colistin in three species of Klebsiella. The study also characterized the genetic contexts of these mcr variants and their association with various plasmid types.

The study reports the first isolation of a Klebsiella pneumoniae strain co-producing OXA-181, CTX-M-55, and MCR-8, highlighting the emergence of multidrug-resistant strains with resistance to carbapenems and colistin.

The study identified blaNDM-5 and mcr-8.1 as the main resistance genes in carbapenem-resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae isolated from animal farms, well water, and human feces in Eastern China.

The study identifies an mcr-8.2-harboring hypervirulent ST412 Klebsiella pneumoniae strain from pediatric sepsis, highlighting the emergence of colistin resistance in this pathogen.

The study identified various antimicrobial resistance genes in E. coli isolates from natural water sources in upper northeast Thailand, including mcr-1, mcr-8, mcr-9, bla oxa-48-like, aac(6')-bl-cr, qepA, and oqxAB, which confer resistance to polymyxin, carbapenem, aminoglycoside, and fluoroquinolone antibiotics.

The study reports a highly drug-resistant ST656 Klebsiella pneumoniae strain, KP15-652, exhibiting high-level colistin resistance mediated by mcr-1.1, mcr-8.2, and crrB mutations, alongside tigecycline resistance conferred by tmexCD1-toprJ1, tet(A), and tet(M).

Disulfiram (DSF) and its derivatives enhance the efficacy of carbapenems and colistin against multidrug-resistant (MDR) Gram-negative bacteria by inhibiting NDM-beta-lactamases and MCR-phosphoethanolamine transferases, reducing resistance and preventing the evolution of drug-resistant strains.

The study identifies mcr-8.1 and tmexCD1-toprJ1 as key genes contributing to colistin and tigecycline resistance in clinical Klebsiella pneumoniae isolates, facilitated by IS26-mediated plasmid recombination.

The study identifies the mcr-8 gene as a key factor in the spread of colistin resistance through the gut microbiome of houseflies, demonstrating its transfer to various bacterial hosts including clinically relevant pathogens.

The study identifies mcr-8 and mcr-9 genes in carbapenem-resistant Klebsiella pneumoniae complex isolates from Thailand, highlighting their role in colistin resistance. It also characterizes additional AMR genes such as bla NDM-1, bla IMP-14, and various other resistance determinants.

Two K. pneumoniae isolates, KP26 and KP29, were found to carry the mcr-8 gene and the tmexCD1-toprJ1 gene cluster on separate plasmids, contributing to colistin and tigecycline resistance, respectively.

Seven ST11-K1 CR-hvKP isolates were found to carry highly homologous blaKPC-2-bearing plasmids, demonstrating multidrug resistance and hypervirulence. Key resistance genes included blaKPC-2, blaSHV-11, blaSHV-12, blaCTX-M-65, blaTEM-1, rmtB, oqxB, tetA/B, sul4, mcr-8, fosA, and mupB.

The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.

The study identifies that ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro, with resistance mutations already present in natural populations and mobile resistance genes prevalent in clinical isolates, soil, and human gut microbiomes.

The study identifies multiple beta-lactamase genes (blaLAP-2, blaTEM-1, blaSHV-11, blaOXA-1) and the mcr8.1 gene, which confers resistance to colistin, in a multidrug-resistant K. pneumoniae ST656 isolate from Bangladesh. Additionally, the qacEdelta1 gene, which contributes to resistance against disinfectants and antibiotics, was detected.

The study shows that vitamin B6 (pyridoxal 5'-phosphate) can resensitize mcr-1 carrying bacteria to colistin by enhancing proton motive force and inducing ferroptosis-like death.

The study identifies the widespread presence of bla NDM-5 and mcr genes in multidrug-resistant gram-negative bacteria isolated from commercial chicken farms in China, highlighting the role of plasmids in the dissemination of these resistance determinants.

The study identifies the widespread presence of bla NDM-5 and mcr genes in multidrug-resistant gram-negative bacteria isolated from commercial chicken farms in China, highlighting the role of plasmids in the dissemination of these resistance determinants.

The study identified several AMR genes, including oqxAB, fosA, blaSHV, and mcr-8.1, in Klebsiella spp. isolates from clinically ill animals. These genes conferred resistance to quinolones, phenicols, fosfomycin, beta-lactams, and colistin, respectively.

The study identified mgrB inactivation as the primary mechanism of colistin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates, with mcr-1.1 and mcr-8.2 genes also contributing to resistance. Mutations in pmrB, pmrA, and phoQ were also associated with colistin resistance.

The paper discusses the emergence and spread of plasmid-mediated MCR genes (MCR-1 to MCR-10) that confer colistin resistance in Gram-negative bacteria, emphasizing their role in reducing the efficacy of colistin as a last-resort antibiotic.

The study identifies novel plasmid-encoded resistance genes, including bla_NDM-1, mcr-8.1, and tporJ1-tmexCD1, in Klebsiella strains isolated from hospital wastewater, highlighting the role of plasmids in the spread of multidrug resistance.

The study identifies mcr-8.2-positive Klebsiella pneumoniae isolates from layer chickens in Xinjiang, China, highlighting the presence of colistin resistance mediated by the mcr-8.2 gene on an IncFII plasmid.