Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump
Overview
Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance.
The study investigates the interplay between different efflux pumps in Escherichia coli and Pseudomonas aeruginosa, demonstrating that simultaneous expression of multiple efflux pumps can lead to either additive or multiplicative effects on drug resistance.
In vivo titration of mitomycin C action by four Escherichia coli genomic regions on multicopy plasmids.
The study identifies four E. coli genes (mdfA, gyrI, rob, and sdiA) that confer resistance to mitomycin C when expressed in multicopy plasmids. These genes were validated through plasmid-based overexpression and zone of inhibition assays.
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.
The study identified that the deletion of tolC and acrAB significantly increased susceptibility to various antibiotics, antiseptics, detergents, and dyes in Escherichia coli. Additionally, mdfA and emrE were found to contribute to resistance against specific compounds.
Correlation of overexpression of efflux pump genes with antibiotic resistance in Escherichia coli Strains clinically isolated from urinary tract infection patients.
Overexpression of marA, mdfA, and yhiV efflux pump genes is associated with increased resistance to various antibiotics in Escherichia coli strains isolated from urinary tract infection patients.
A Contribution of MdfA to Resistance to Fluoroquinolones in Shigella flexneri.
The study shows that mdfA contributes to fluoroquinolone resistance in Shigella flexneri, although it is not a major effector of high resistance levels.
Examination of Quaternary Ammonium Compound Resistance in Proteus mirabilis Isolated from Cooked Meat Products in China.
The study identified quaternary ammonium compound resistance genes, including mdfA, ydgE/ydgF, qacE, qacEΔ1, emrE, sugE(c), sugE(p), and qacH, in foodborne Proteus mirabilis isolates. It also discovered non-classic class 1 integrons carrying the gene structure qacH-IS440-sul3, which were located on conjugative plasmids, facilitating the co-dissemination of antimicrobial and disinfectant resistance genes.
Whole-Genome Sequences of Five Acinetobacter baumannii Strains From a Child With Leukemia M2.
Five multidrug-resistant Acinetobacter baumannii strains from a child with leukemia M2 were characterized. They harbored blaOXA-51 and blaOXA-23 genes, which confer resistance to carbapenems.
Nasal Resistome Development in Infants With Cystic Fibrosis in the First Year of Life.
The study identified various antimicrobial resistance genes in the nasal microbiome of infants with cystic fibrosis, including beta-lactamases, chloramphenicol efflux pumps, tetracycline resistance proteins, and enzymes involved in folic acid synthesis inhibition.
Florfenicol Resistance in Enterobacteriaceae and Whole-Genome Sequence Analysis of Florfenicol-Resistant Leclercia adecarboxylata Strain R25.
The study identifies the floR gene as a major contributor to florfenicol resistance in Enterobacteriaceae, particularly in Leclercia adecarboxylata strain R25. Other resistance genes such as mdfA, aac(6')-Ib-cr, aadA16, qnrB6, sul1, dfrA27, arr-3, and qacEΔ1 were also characterized.
Rapid, multiplexed, whole genome and plasmid sequencing of foodborne pathogens using long-read nanopore technology.
The study identifies the multidrug resistance gene Mdf(A) in Escherichia coli O157:H7, which confers resistance to macrolides, lincosamides, and streptogramin B.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Genome-Based Analysis of Extended-Spectrum β-Lactamase-Producing Escherichia coli in the Aquatic Environment and Nile Perch (Lates niloticus) of Lake Victoria, Tanzania.
The study identified multiple AMR genes in ESBL-producing E. coli from Nile perch and water samples in Lake Victoria, including bla CTX-M-15, bla TEM-1B, aadA2, aac(3)-IId, sul1, sul2, dfrA12, qepA4, tetB, tetD, mphA, mdfA, catA1, strA, strB, nfaE, iss, vat, and lpfA.
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
The study identified 22 AMR genes in 10 ocular E. coli isolates, including bla CTX-M-15, dfrA17, aadA2, aadA5, bla OXA-1, bla NDM-5, dfrA12, bla TEM-1 B, mdfA, emrB, mphA, sul1, sul2, and aac(6')-1b-cr. Additionally, chromosomal mutations in parE, gyrA, and parC were found to confer resistance to fluoroquinolones.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Impact of short-term storage on the quantity of extended-spectrum beta-lactamase-producing Escherichia coli in broiler litter under practical conditions.
The study identified bla SHV-12, bla CTX-M-1, and bla TEM-1 as the primary beta-lactamase genes in ESBL-producing E. coli isolates from broiler litter. Additional resistance mechanisms included qnrS1, mdfA, and Tet 34.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Comparison of antimicrobial resistant genes in chicken gut microbiome grown on organic and conventional diet.
The study identified various antimicrobial resistance genes in the gut microbiome of chickens raised on organic and conventional diets, including beta-lactamases, multidrug efflux systems, aminoglycoside modifying enzymes, and tetracycline resistance genes. These genes were found to be more prevalent in conventional diet samples under higher antibiotic concentrations.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Isolation and characterization of Uropathogenic Escherichia coli (UPEC) from red panda (Ailurus fulgens).
The study identified a Uropathogenic Escherichia coli (UPEC) strain isolated from a red panda that exhibited resistance to multiple antibiotics, including aminoglycosides, beta-lactams, and macrolides. The strain possessed 20 resistance genes, such as acra, acrb, mdte, mdtf, mdtn, mdto, mdtp, tolc, arna, baca, bcr, bl1_ec, emre, ksga, macb, mdfa, mdtg, mdth, mdtk, and mdtl, which contribute to multidrug resistance.
Molecular Characteristics of Extraintestinal Pathogenic E. coli (ExPEC), Uropathogenic E. coli (UPEC), and Multidrug Resistant E. coli Isolated from Healthy Dogs in Spain. Whole Genome Sequencing of Canine ST372 Isolates and Comparison with Human Isolates Causing Extraintestinal Infections.
The study identified several AMR genes in canine ST372 isolates, including blaTEM-1A, sul1, aadA1, dfrA1, and mdf(A), which confer resistance to beta-lactams, sulfonamides, aminoglycosides, trimethoprim, and tetracyclines respectively. These genes were found in the genomes of the isolates through whole genome sequencing and in silico analysis.
Genomic Characterization of Salmonella Minnesota Clonal Lineages Associated with Poultry Production in Brazil.
The study identified multiple antimicrobial resistance genes, including aac(6')-Iaa, mdf(A), sul2, tet(A), blaCMY-2, aph(3')-Ia_1, qnrB19, and ant(3'')-Ia, in Salmonella Minnesota isolates from Brazilian poultry farms, indicating widespread resistance to various antibiotics.
Genomic characterization of enteropathogenic Escherichia coli (EPEC) of avian origin and rabbit ileal loop response; a pet macaw (Ara chloropterus) as a possible zoonotic reservoir.
The study identified an EPEC strain from a pet macaw, MA-81, which exhibited resistance to macrolide, lincosamide, and streptogramin B antibiotics due to the presence of the mdf(A) gene.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-8, bla CTX-M-27, bla CTX-M-14, and bla CTX-M-55, along with mcr-1.1 and mcr-3.1 for colistin resistance. Additionally, various other resistance genes such as qnrS1, mdf(A), mph(A), and others were found in the isolates, indicating multidrug resistance.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
The study identified various AMR genes and mutations in Gram-negative bacteria isolated from chronic wounds in Ghana, including beta-lactamases, fosfomycin resistance genes, chloramphenicol resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, tetracycline resistance genes, sulfonamide resistance genes, trimethoprim resistance genes, and efflux pumps. Mutations in gyrA, parE, and parC were also found to contribute to fluoroquinolone resistance.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.
The study reports an outbreak of NDM-1-producing Klebsiella pneumoniae in an ICU during the COVID-19 pandemic, highlighting the presence of multiple AMR genes including blaNDM-1, blaTEM-1, blaCTX-M-15, blaOXA-1, blaCMY-4, and others, along with mutations in ParC and GyrA contributing to quinolone resistance.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
The Evolution of Fluoroquinolone Resistance in Salmonella under Exposure to Sub-Inhibitory Concentration of Enrofloxacin.
Decreasing the abundance of tetracycline-resistant Escherichia coli in pig feces during nursery using flavophospholipol as a pig feed additive.
Flavophospholipol (FPL) effectively reduced the abundance of tetracycline-resistant Escherichia coli in pig feces by inhibiting conjugational transfer and growth of resistant plasmids carrying tetA, tetB, blaTEM-1B, mdfA, aph(3')-I, sul2, aadA1, and dfrA1.
Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance.
The study evaluated the combination of flomoxef and fosfomycin for treating neonatal sepsis in settings with high antimicrobial resistance. It found that the combination showed synergy in bacterial killing and prevented the emergence of fosfomycin resistance. Specific AMR genes and mutations were identified in Enterobacterales strains, including beta-lactamases and efflux pumps.
Similarities in Virulence and Extended Spectrum Beta-Lactamase Gene Profiles among Cefotaxime-Resistant Escherichia coli Wastewater and Clinical Isolates.
The study identifies several beta-lactamase genes, including blaCTX-M-1, blaKPC-2, blaTEM-350, blaOXA-1, and blaCTX-M-15, as well as various aminoglycoside, macrolide, and tetracycline resistance genes in cefotaxime-resistant E. coli isolates from hospital and urban wastewater. Mutations in parC, parE, and gyrA contribute to fluoroquinolone resistance.
Genomic Analysis of Escherichia coli Longitudinally Isolated from Broiler Breeder Flocks after the Application of an Autogenous Vaccine.
The study identified 25 antimicrobial resistance genes in E. coli isolates from broiler breeder flocks, with mdf(A) and sitABCD being the most prevalent. Tet(A) was also detected, primarily in Farm A.
HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities.
The study identified various AMR genes, including aadA1, aadA2, blaCFE-1, cmlA1, dfrA12, mdf(A), sul3, tet(34), and lnu(A), in pig fecal microbiomes. Notably, the lnu(A) gene was exclusively found in conventional farms and associated with Lactobacillus species.
Dissemination of Resistant Escherichia coli Among Wild Birds, Rodents, Flies, and Calves on Dairy Farms.
The study identified the mdfA gene encoding the MdfA multi-drug efflux pump in Escherichia coli isolates from dairy farms, which confers resistance to ampicillin and trimethoprim.
Occurrence and Genomic Characterization of Clone ST1193 Clonotype 14-64 in Uncomplicated Urinary Tract Infections Caused by Escherichia coli in Spain.
The study identified the occurrence of fluoroquinolone-resistant ST1193 clone in uncomplicated urinary tract infections (uUTI) caused by Escherichia coli in Spain. Several AMR genes and mutations were characterized, including blaTEM-1B, aph(3')-Ib, aph(6)-Id, mdf(A), mph(A), sul2, dfrA14, dfrA17, sitABCD, and chromosomal mutations in gyrA (S83L, D87N), parC (S80I), and parE (L416F).
Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America.
The study identifies a multidrug-resistant NDM-1-producing E. coli ST162 strain isolated from a pygmy sperm whale, highlighting the presence of various AMR genes including blaNDM-1, blaTEM-1C, blaOXA-1, and others, as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
OXA-244-Producing ST131 Escherichia coli From Surface and Groundwaters of Pavia Urban Area (Po Plain, Northern Italy).
The study identified OXA-244-producing ST131 Escherichia coli in surface and groundwater samples from Pavia, Italy. Key resistance genes included bla CTX-M-type, bla OXA-244, aac(6')-Ib-cr, and qnrS.
Highly Virulent and Multidrug-Resistant Escherichia coli Sequence Type 58 from a Sausage in Germany.
The study identified a highly virulent and multidrug-resistant Escherichia coli strain ST58 from a pork sausage in Germany, carrying resistance genes for beta-lactams, macrolides, streptomycin, sulfonamides, and diaminopyrimidines, along with heavy metal resistance genes.
Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China.
The study identified mcr-1, tet(X4), and blaNDM-5 genes in Escherichia coli from food animals in eastern China, highlighting their role in resistance to colistin, tigecycline, and meropenem, respectively. These genes were found to be transferable via plasmids, emphasizing the potential for spread of antimicrobial resistance.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment.
The study identified a multidrug-resistant ST648 E. coli isolate carrying various AMR genes, including blaCTX-M-2, blaCMY-2, qnrB, tetB, sul1, sul2, aadA1, aac(3)-VIa, and mdfA, highlighting the presence of critical priority pathogens in wild birds.
Whole-genome sequencing-based characteristics of Escherichia coli Rize-53 isolate from Turkey.
The study identified ten antibiotic resistance genes in the E. coli Rize-53 isolate, including blaOXA-1, blaOXA-2, aac(6')-II, aac(6')-Ib-cr, tetB, catB3, qacE, sitABCD, mdfA, and sul2, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, and quaternary ammonium compounds.
Phenotypic and genotypic characterization of antimicrobial resistance profiles in Salmonella isolated from waterfowl in 2002-2005 and 2018-2020 in Sichuan, China.
The study identified multiple AMR genes and mutations in Salmonella isolates from waterfowl in Sichuan, China, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and quinolone resistance genes. Mutations in gyrA and gyrB were associated with nalidixic acid resistance.
Isolation of extended-spectrum β-lactamase-producing Escherichia coli from Japanese red fox (Vulpes vulpes japonica).
Two CTX-resistant Escherichia coli strains were isolated from Japanese red fox fecal samples, harboring various AMR genes and mutations. One strain carried aph(3")-Ib, aph(3')-Ia, aph(6)-Id, mdf(A), sitABCD, sul2, tet(A), and tet(B), while the other had gyrA(S83L), parC(S80I, E84V), and parE(I529L) mutations along with mdf(A) and sitABCD.
Vaginal Bacteria in Mares and the Occurrence of Antimicrobial Resistance.
The study identified several AMR genes in E. coli isolates from mares, including dfrA14 for trimethoprim resistance, mdf(A) for chloramphenicol resistance, sul2 for sulfonamide resistance, blaEC for beta-lactam resistance, and aph(6)-Id for streptomycin resistance.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Hybrid Genomic Analysis of Salmonella enterica Serovar Enteritidis SE3 Isolated from Polluted Soil in Brazil.
The study identified several antimicrobial resistance genes in Salmonella enterica serovar Enteritidis SE3, including aac(6')-Iaa, mdfA, golS, and msbA, which confer resistance to aminoglycosides, tetracycline, monobactam, and nitroimidazole, respectively.
Metagenomic analysis reveals patterns and hosts of antibiotic resistance in different pig farms.
The study identified various antibiotic resistance genes (ARGs) in pig manure samples from different regions of Shanxi, China, highlighting the prevalence of tetracycline, aminoglycoside, macrolide, and phenicol resistance genes. Key ARGs included tet(W), tet(40), tet(Q), erm(B), erm(F), mef(A), aph(3')-III, ant(6)-Ia, cfr(C), floR, blaACI-1, optrA, cat, cfxA4, cfxA5, blaCTX-M-105, blaCTX-M-65, fexB, erm(T), mdf(A), and ole(B).
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
Prevalence and Persistence of Antibiotic Resistance Determinants in the Gut of Travelers Returning to the United Kingdom is Associated with Colonization by Pathogenic Escherichia coli.
The study identified various antibiotic resistance genes in the gut microbiota of travelers returning to the UK, highlighting the association with colonization by pathogenic E. coli. Key findings include the prevalence of genes conferring resistance to macrolides, tetracyclines, sulfonamides, and others.
Genomic Characteristics of a Multidrug-Resistant ST648 Escherichia coli Isolate Co-Carrying bla(KPC-2) and bla(CTX-M-15) Genes Recovered from a Respiratory Infection in China.
The study identifies a multidrug-resistant ST648 Escherichia coli isolate carrying bla(KPC-2) and bla(CTX-M-15) genes, along with other resistance genes such as tet(B), mdf(A), mph(A), dfrA17, aadA5, and sul1.
Phylodynamics Uncovers the Transmission of Antibiotic-Resistant Escherichia coli between Canines and Humans in an Urban Environment.
The study identifies several AMR genes, including bla TEM-1B, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, and mdf(A), in antibiotic-resistant E. coli isolates from human and canine fecal samples in San Francisco. These genes confer resistance to various antibiotics, highlighting the transmission of AMR between canines and humans.
Unraveling virulence determinants in extended-spectrum beta-lactamase-producing Escherichia coli from East Africa using whole-genome sequencing.
The study identified several AMR genes in ESBL-producing E. coli isolates from Uganda and Tanzania, including blaCTX-M-15, blaCTX-M-27, blaTEM-1B, mdfA, tet(B), sul1, tet(A), and sul2, which confer resistance to beta-lactams, fluoroquinolones, third-generation cephalosporins, chloramphenicol, tetracyclines, and sulfonamides.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
Development of a portable on-site applicable metagenomic data generation workflow for enhanced pathogen and antimicrobial resistance surveillance.
The study characterizes several antimicrobial resistance genes, including tet(W), tet(Q), mdf(A), erm(B), lsa(A), and aac(6')-Iaa, through the use of a spiked-in mock community and long-read sequencing.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
Comparative genomics analysis and characterization of Shiga toxin-producing Escherichia coli O157:H7 strains reveal virulence genes, resistance genes, prophages and plasmids.
Five resistance genes were identified in E. coli O157:H7 strains, including tet(B), sul2, aph(3"-Ib), aph(6)-Id, and mdf(A).
Prevalence, antibiotic resistance and molecular characterization of Staphylococcus aureus in ready-to-eat fruits and vegetables in Shanghai, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from ready-to-eat fruits and vegetables in Shanghai, China, including genes conferring resistance to beta-lactams, fluoroquinolones, aminoglycosides, lincosamides, and fosfomycin.
A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli.
The review discusses the mechanisms of antibiotic resistance in pathotypes of E. coli, focusing on the role of beta-lactamases, carbapenemases, and other resistance genes. It highlights the importance of understanding these mechanisms to combat the growing problem of antibiotic resistance.
Genotypic and phenotypic characterisation of asymptomatic bacteriuria (ABU) isolates displaying bacterial interference against multi-drug resistant uropathogenic E. Coli.
The study identified the mdfA gene in all ABU isolates, which confers resistance to a broad spectrum of antibiotics. E. coli S-07-4 was found to harbor multiple resistance genes, indicating potential multidrug resistance.
Genomic Dissection of an Enteroaggregative Escherichia coli Strain Isolated from Bacteremia Reveals Insights into Its Hybrid Pathogenic Potential.
The study identifies multiple efflux pump-encoding genes in the E. coli strain EC092, which contribute to its resistance against several antibiotics including tetracycline, trimethoprim, streptomycin, and sulfamethoxazole.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail markets in Yichun city, China, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, trimethoprim, and extended-spectrum beta-lactamases.
Genomic insights into antimicrobial resistance and virulence of E. coli in central Ethiopia: a one health approach.
The study identified multiple antimicrobial resistance genes (ARGs) in E. coli isolates from central Ethiopia, including bla-ampH, bla-AmpC1, tet(A), mdf(A), aph(3")-Ib, sul2, and aph(6)-Id. Chromosomal mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Whole-genome sequencing and bioinformatic tools powered by machine learning to identify antibiotic-resistant genes and virulence factors in Escherichia coli from sepsis.
The study identified several known and novel antibiotic-resistant genes in E. coli isolates from sepsis patients using whole-genome sequencing and machine learning. Key findings include the presence of blaCTX-M, blaSHV, blaTEM, aac(6')-Ib, aadA, qnrS1, ermB, mexAB-OprM, acrAB-TolC, and oqxAB genes, which confer resistance to various antibiotics.
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