mdfA
efflux pump
Overview
- Mechanism
- confers resistance to extreme alkaline pH by maintaining internal pH
- Validation Method
- MIC determination
- Drug Classes
- chloramphenicol, tetracycline, ethidium bromide, benzalkonium chloride, alkaline ph
- Organisms
- Escherichia coli, Escherichia coli W3110
- Papers
- 3
- Databases
- Reslit
Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance.
The study investigates the interplay between different efflux pumps in Escherichia coli and Pseudomonas aeruginosa, demonstrating that simultaneous expression of multiple efflux pumps can lead to either additive or multiplicative effects on drug resistance.
Gene Information
- Gene Name
- mdfA
- Allele
- mdfA
- Encodes
- efflux pump
- Source Database
- Reslit
- Confers Resistance To
- chloramphenicoltetracycline
- Organisms Tested In
- • Escherichia coli
- Validation Method
- MIC determination
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.
The study identified that the deletion of tolC and acrAB significantly increased susceptibility to various antibiotics, antiseptics, detergents, and dyes in Escherichia coli. Additionally, mdfA and emrE were found to contribute to resistance against specific compounds.
Gene Information
- Gene Name
- mdfA
- Allele
- mdfA
- Encodes
- major facilitator superfamily (MFS) efflux pump
- Source Database
- Reslit
- Confers Resistance To
- ethidium bromidebenzalkonium chloride
- Organisms Tested In
- • Escherichia coli W3110
- Validation Method
- agar dilution MIC test
Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis.
The study identifies MdfA, a multidrug transporter, as a critical factor in conferring resistance to extreme alkaline pH in E. coli by maintaining internal pH homeostasis.
Gene Information
- Gene Name
- mdfA
- Allele
- mdfA
- Encodes
- multidrug transporter
- Source Database
- Reslit
- Mechanism
- confers resistance to extreme alkaline pH by maintaining internal pH
- Confers Resistance To
- alkaline ph
- Organisms Tested In
- • Escherichia coli
- Validation Method
- expression in E. coli and growth assays under alkaline conditions
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