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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| mdrl | Reslit | 1 | Benzalkonium chloride | Listeria monocytogenes | - | 2006 | - | - |
| MdrL | Reslit | 1 | Benzalkonium chloride |
| - |
| 2009 |
| - |
| - |
Role of efflux pumps in adaptation and resistance of Listeria monocytogenes to benzalkonium chloride.
The study identified the efflux pumps MdrL and Lde in Listeria monocytogenes, demonstrating their roles in resistance to benzalkonium chloride and other antimicrobials. MdrL was found to be significantly upregulated upon adaptation to benzalkonium chloride, suggesting its involvement in the adaptation process.
Efflux-mediated drug resistance in bacteria: an update.
The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.
Resistance to Biocides in Listeria monocytogenes Collected in Meat-Processing Environments.
The study identifies the non-specific efflux pumps lde and mdrL as contributing to benzalkonium chloride resistance in Listeria monocytogenes strains isolated from meat-processing environments.
MdrL, a major facilitator superfamily efflux pump of Listeria monocytogenes involved in tolerance to benzalkonium chloride.
The study identifies MdrL, a chromosomal major facilitator superfamily efflux pump, as crucial for Listeria monocytogenes' tolerance to benzalkonium chloride. Deletion of mdrL impairs growth in the presence of sublethal concentrations of BC, and complementation restores the phenotype. LadR negatively regulates mdrL expression.
Effect of Benzalkonium Chloride Adaptation on Sensitivity to Antimicrobial Agents and Tolerance to Environmental Stresses in Listeria monocytogenes.
The study identified the efflux pump gene mdrL as being involved in benzalkonium chloride (BC) adaptation in Listeria monocytogenes. The expression of mdrL was significantly upregulated in BC-adapted strains, and its deletion impaired growth in the presence of BC.
Does Shiga Toxin-Producing Escherichia coli and Listeria monocytogenes Contribute Significantly to the Burden of Antimicrobial Resistance in Uruguay?
The study identified several antimicrobial resistance genes in Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes isolates, including aph(3")-Ib, aph(3′)-Ia, aph(6)-Id, blaTEM-1B, sul2, tet(A), fosX, lin, norB, lde, mdrL, and fepA. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, fosfomycin, lincomycin, ciprofloxacin, and erythromycin.
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