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mecA2

PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA2

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mecA2

Browse AMR rules for mecA2

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: clone in E. coli and MIC testing
Drug Classes: PIPERACILLIN+TAZOBACTAM, MEROPENEM, ERTAPENEM, AMOXICILLIN, CEFOXITIN, IMIPENEM, CEFIXIME, CEFEPIME, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, METHICILLIN, PIPERACILLIN, Beta-lactams
Organisms: Mammaliicoccus vitulinus, Staphylococcus epidermidis
Geographic Location: Europe, Europe|USA
Alleles: 3
Papers: 5
Databases: Reference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
MecA2	Reference Gene CatalogResFinder DatabaseReslit	5	PIPERACILLIN+TAZOBACTAM, MEROPENEM +14	Mammaliicoccus vitulinus	Europe	2006, 2010, 2025

Papers5

1

Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.

PMID 17005735 · 2006

Gene Information

Gene Name: mecA2
Allele: MecA2
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA2
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Mammaliicoccus vitulinus
Sequence Accession: AM048810.2
Protein Accession: CAJ15587.2

2

Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.

PMID 17005735 · 2006

Gene Information

Gene Name: mecA2
Allele: MecA2
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA2
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Mammaliicoccus vitulinus
Sequence Accession: AM048810.2
Protein Accession: CAJ15587.2

3

Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission., Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.

PMID 17005735, 20679504 · 2006

Gene Information

Gene Name: mecA2
Allele: mecA2
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Mammaliicoccus vitulinus
Sequence Accession: AM048811, AB546780

4

Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.

PMID 20679504 · 2010

Gene Information

Gene Name: mecA2
Allele: MecA2
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA2
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Mammaliicoccus vitulinus
Sequence Accession: AB546780.1
Protein Accession: BAJ14745.2

5

Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.

PMID 20679504 · 2010

Gene Information

Gene Name: mecA2
Allele: MecA2
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA2
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Mammaliicoccus vitulinus
Sequence Accession: AB546780.1
Protein Accession: BAJ14745.2

6

Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.

PMID 40732675 · 2025

The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.

Gene Information

Gene Name: mecA2
Allele: mecA_2
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase
Source Database: Reslit
Confers Resistance To: Beta-lactams
Organisms Tested In: • Staphylococcus epidermidis
Geographic Location: Europe|USA
Validation Method: clone in E. coli and MIC testing
Sequence Accession: PRJNA1262472

7

Diversification of the Staphylococcal Cassette Chromosome Through Distinct Mechanisms of Horizontal Transfer.

PMID 41220211 · 2025

The study identifies a wide distribution of mec genes across various Staphylococcaceae species, highlighting the diversity of SCC mec elements and their mechanisms of horizontal transfer.

Gene Information

Gene Name: mecA2
Allele: MecA2
Encodes: alternative penicillin-binding protein (PBP2a)
Source Database: Reslit
Mechanism: confers resistance to beta-lactam antibiotics
Confers Resistance To: Beta-lactams
Organisms Tested In: • Mammaliicoccus vitulinus
Geographic Location: Europe
Validation Method: annotation by Prokka and SCCeeker
Sequence Accession: ASM2969181v1|ASM2436350v1