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mecC2

PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecC2

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mecC2

Browse AMR rules for mecC2

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: annotation by Prokka and SCCeeker
Drug Classes: PIPERACILLIN+TAZOBACTAM, MEROPENEM, ERTAPENEM, AMOXICILLIN, CEFOXITIN, IMIPENEM, CEFIXIME, CEFEPIME, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, METHICILLIN, PIPERACILLIN, Beta-lactams
Organisms: Mammaliicoccus sciuri, Staphylococcus saprophyticus, Mammaliicoccus lentus
Geographic Location: Europe
Alleles: 2
Papers: 3
Databases: Reference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
MecC2	Reference Gene CatalogResFinder DatabaseReslit	3	PIPERACILLIN+TAZOBACTAM, MEROPENEM +14	Mammaliicoccus sciuri +1	Europe

Papers3

1

A novel hybrid SCCmec-mecC region in Staphylococcus sciuri.

PMID 24302651 · 2014

Gene Information

Gene Name: mecC2
Allele: MecC2
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecC2
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Mammaliicoccus sciuri
Sequence Accession: HG515014.1
Protein Accession: CDH98053.1

2

A novel hybrid SCCmec-mecC region in Staphylococcus sciuri.

PMID 24302651 · 2014

Gene Information

Gene Name: mecC2
Allele: MecC2
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecC2
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Mammaliicoccus sciuri
Sequence Accession: HG515014.1
Protein Accession: CDH98053.1

3

Detection of a new mecC allotype, mecC2, in methicillin-resistant Staphylococcus saprophyticus.

PMID 24569631 · 2014

Gene Information

Gene Name: mecC2
Allele: mecC2
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Staphylococcus saprophyticus
Sequence Accession: KF955540

4

Diversification of the Staphylococcal Cassette Chromosome Through Distinct Mechanisms of Horizontal Transfer.

PMID 41220211 · 2025

The study identifies a wide distribution of mec genes across various Staphylococcaceae species, highlighting the diversity of SCC mec elements and their mechanisms of horizontal transfer.

Gene Information

Gene Name: mecC2
Allele: MecC2
Encodes: alternative penicillin-binding protein (PBP2a)
Source Database: Reslit
Mechanism: confers resistance to beta-lactam antibiotics
Confers Resistance To: Beta-lactams
Organisms Tested In: • Mammaliicoccus lentus
Geographic Location: Europe
Validation Method: annotation by Prokka and SCCeeker
Sequence Accession: ASM2969181v1|ASM2436350v1