Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
mecA-type methicillin resistance repressor MecI
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| N121K | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| A11V | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| I31M | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| L52* | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| Q68* | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| E115* | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| L116S | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| D39G | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| P42L | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| L48F | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| R51I | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
Research Article
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
Research Article
Methicillin-resistance in Staphylococcus aureus is not affected by the overexpression in trans of the mecA gene repressor: a surprising observation.
Research Article
The study shows that overexpression of mecI does not significantly alter oxacillin resistance levels in most MRSA strains, indicating that other factors may influence mecA regulation and β-lactam resistance.
Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA).
Research Article
Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA).
Research Article
The Effect of Iodine-Containing Nano-Micelles, FS-1, on Antibiotic Resistance, Gene Expression and Epigenetic Modifications in the Genome of Multidrug Resistant MRSA Strain Staphylococcus aureus ATCC BAA-39.
Research Article
The study shows that FS-1 induces antibiotic resistance reversion in MRSA strain S. aureus ATCC BAA-39, with significant reductions in methicillin resistance and changes in gene expression patterns. The SCC mec cassette, containing mecA and mecR, showed decreased coverage in both NC and FS genomes.
Regulation of virulence and β-lactamase gene expression in Staphylococcus aureus isolates: cooperation of two-component systems in bloodstream superbugs.
Research Article
The study characterizes the molecular relationships between two-component systems of virulence factors and the expression of the β-lactamase gene in MRSA-BSI isolates, highlighting the role of genes such as mecA, blaZ, mecI, mecRI, sarA, RNAIII, and SaeRS in β-lactam resistance.
A prevalence and molecular characterization of novel pathogenic strains of Macrococcus caseolyticus isolated from external wounds of donkeys in Khartoum State -Sudan.
Research Article
The study identified a novel strain of Macrococcus caseolyticus, DaniaSudan, which exhibits resistance to several antibiotics, including ciprofloxacin, ceftazidime, erythromycin, oxacillin, clindamycin, and kanamycin. The strain was found to possess resistance genes such as ANT(4')-Ib, mecA, mecI, mecR1, and Tet(38).
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
Research Article
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Sub-MIC streptomycin and tetracycline enhanced Staphylococcus aureus Guangzhou-SAU749 biofilm formation, an in-depth study on transcriptomics.
Research Article
The study identified several AMR genes in S. aureus Guangzhou-SAU749, including ermB, mecA, mecR1, mepA, aad(6), tet(38), and others. These genes were associated with resistance to various antibiotics. Additionally, the study found that sub-MIC concentrations of streptomycin and tetracycline enhanced biofilm formation, which was linked to the regulation of genes such as arlR, hssR, tagA, clfB, and atlA.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
Research Article
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.
Research Article
The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.
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