Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
beta-lactam sensor/signal transducer MecR1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| MecR1 | Card DatabaseReference Gene CatalogReslit | 17 | METHICILLIN, Methicillin +5 | Staphylococcus aureus subsp. aureus Mu50 +6 | Michigan, USA, China|South Korea, Yunnan, China, Khartoum State, Sudan, Benin, Shanghai, China, Malaysia, Europe|USA, Europe, New Zealand, Europe|Norway|Romania, Saudi Arabia | 2001, 2019, 2021, 2022, 2023, 2024, 2025 | BA000017.4 | BAB56204.1 |
| mecR1 | Card Database | 1 | - | Staphylococcus aureus subsp. aureus JH9 | - | - | CP000703.1 | ABQ47844.1 |
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus.
The study shows that sanguisorbigenin (SGB) exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and enhances the efficacy of beta-lactam antibiotics. SGB reduces the expression of mecA, blaR1, and blaZ genes, which are involved in beta-lactam resistance.
Comparative Genomic and Pan-Genomic Characterization of Staphylococcus epidermidis From Different Sources Unveils the Molecular Basis and Potential Biomarkers of Pathogenic Strains.
The study identified several antimicrobial resistance genes in Staphylococcus epidermidis, including norA, dfrC, mecA, mecR1, qacA, aac(6')-Ie-aph(2'')-Ia, msrA, and mgrA, which confer resistance to various antibiotics such as fluoroquinolones, methicillin, and aminoglycosides.
Prevalence and antimicrobial resistance profiling of Staphylococcus aureus isolated from traditional cheese in Yunnan, China.
The study identified 18 antimicrobial resistance genes in Staphylococcus aureus strain DC.RB_015, including mecA, blaZ, mepA, tet(K), tet(38), arlR, arlS, norA, mgrA, LmrS, APH(3′)-IIIa, aad(6), ErmB, SAT-4, mecR1, GlpT, murA, and bacA, which confer resistance to various antibiotics such as methicillin, beta-lactam, tetracycline, fluoroquinolone, macrolide, aminoglycoside, nucleoside, fosfomycin, and bacitracin.
A prevalence and molecular characterization of novel pathogenic strains of Macrococcus caseolyticus isolated from external wounds of donkeys in Khartoum State -Sudan.
The study identified a novel strain of Macrococcus caseolyticus, DaniaSudan, which exhibits resistance to several antibiotics, including ciprofloxacin, ceftazidime, erythromycin, oxacillin, clindamycin, and kanamycin. The strain was found to possess resistance genes such as ANT(4')-Ib, mecA, mecI, mecR1, and Tet(38).
Detecting patterns of accessory genome coevolution in Staphylococcus aureus using data from thousands of genomes.
The study identifies coevolving genes in Staphylococcus aureus, highlighting interactions among antibiotic resistance genes, mobile genetic elements, and virulence factors. Key findings include the coevolution of beta-lactam resistance genes (blaZ, blaI, blaR1), metal resistance genes (cadA, cadC, copB, mco), and plasmid replication genes (repD, repE, repN, pre).
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.
The study identifies AMR genes and mutations associated with the clonal replacement of MRSA strains in a Malaysian hospital, highlighting the role of desiccation tolerance and reduced antibiotic resistance.
Adaptive laboratory-evolved MRSA with PPEF manifests cross-susceptibility to oxacillin and hypersensitivity to ciprofloxacin.
The study identifies the downregulation of several AMR genes, including blaZ, mecR1, kdpB, ble, pbp, and ermA, in PPEF-evolved MRSA-PR strains, leading to increased susceptibility to antibiotics such as oxacillin, ciprofloxacin, gentamicin, and imipenem.
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.
The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.
Antimicrobial Activities of Propolis Nanoparticles in Combination with Ampicillin Sodium Against Methicillin-Resistant Staphylococcus aureus.
Propolis nanoparticles (PNPs) in combination with ampicillin sodium (AS) exhibit synergistic antibacterial and anti-biofilm effects against methicillin-resistant Staphylococcus aureus (MRSA) by downregulating the expression of mecA, mecR1, blaZ, and icaADBC genes.
Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand.
The study identified several AMR genes in Staphylococcus aureus ST1 isolates from New Zealand, including blaZ, tet(38), mecA, mecR1, qacA, qacB, ermC, fusC, mupA, and others. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, methicillin, quaternary ammonium compounds, erythromycin, fusidic acid, mupirocin, and fluoroquinolones. The study also highlighted the presence of a novel prophage, φSabovST1, in bovine ST1 isolates, which encoded bovine-adapted leukocidins.
Antimicrobial resistance reservoirs in salmon and broiler processing environments, sidestreams, and waste discharges.
The study identified several high-risk AMR genes in salmon and broiler processing environments, including multidrug resistance genes TolC and mdtE, tetracycline genes tet(L) and tet(M), aminoglycoside genes APH(3′)-IIIa and APH(6)-Id, and beta-lactam genes mecA and mecR1. Additionally, the study found quinolone-resistant Escherichia coli (QREC) in waste discharges from two broiler processing plants and multidrug resistant (MDR) E. coli in one plant.
Genomic diversity and antimicrobial resistance of Staphylococcus aureus in Saudi Arabia: a nationwide study using whole-genome sequencing.
The study identified multiple AMR genes in S. aureus isolates from Saudi Arabia, highlighting the genetic diversity and resistance patterns associated with mass gatherings. Key genes include mecA, mecR1, aacA-aphD, knt, tet(K), ermC, msrA, fcl_1, natA, macB, and dppB, which confer resistance to various antibiotics.
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