Browse AMR Genes

Explore antimicrobial resistance genes from the literature

mef(H)

macrolide efflux protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mef(H)

Browse AMR rules for mef(H)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Linked to macrolide resistance
Validation Method: detection via SRST2 against ResFinder/ARGannot databases
Drug Classes: Macrolide, ERYTHROMYCIN
Organisms: Clostridioides difficile
Geographic Location: Asia|Europe|North America|Australia/New Zealand, South Africa
Alleles: 3
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
mefH	Reslit	2	Macrolide	Clostridioides difficile	Asia\|Europe\|North America\|Australia/New Zealand, South Africa	2021, 2025	BK013348	-
Mef(H)	Reference Gene Catalog

Papers2

1

A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile.

PMID 34793295 · 2021

This study identifies multiple AMR genes and mutations in Clostridioides difficile, including ermB, tetM, mefH, and various mutations in gyrA, gyrB, rpoB, pbp1, and pbp3. These findings highlight the widespread nature of AMR in C. difficile and its potential role in the spread of the bacterium.

Gene Information

Gene Name: mef(H)
Allele: mefH
Encodes: macrolide efflux protein
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Clostridioides difficile
Geographic Location: Asia|Europe|North America|Australia/New Zealand
Validation Method: detection via SRST2 against ResFinder/ARGannot databases
Sequence Accession: BK013348

2

Phenotypic and genotypic antimicrobial resistance profiles of clinical Clostridioides difficile isolates collected from private and public health settings in South Africa.

PMID 40637760 · 2025

The study identified a PnimB promoter mutation associated with reduced metronidazole susceptibility in ST1 strains, a Thr82Ile mutation in gyrA linked to fluoroquinolone resistance, and various efflux pump and resistance genes such as qacG, aac(6')-Ie-aph(2'')-Ia, ermB, tetM, and CDD-1/CDD-2. High multidrug resistance (MDR) was observed in ST1 and ST37 strains.

Gene Information

Gene Name: mef(H)
Allele: mefH
Encodes: Macrolide efflux protein H
Source Database: Reslit
Mechanism: Linked to macrolide resistance
Confers Resistance To: Macrolide
Organisms Tested In: • Clostridioides difficile
Geographic Location: South Africa
Validation Method: Whole genome sequencing
Sequence Accession: PRJNA1138394

3

Gene Information

Gene Name: mef(H)
Allele: Mef(H)
Encodes: macrolide efflux MFS transporter Mef(H)
Source Database: Reference Gene Catalog
Confers Resistance To: ERYTHROMYCIN
Organisms Tested In: • Clostridioides difficile
Sequence Accession: AAXWAM010000007.1
Protein Accession: EGT5231013.1

4

Gene Information

Gene Name: mef(H)
Allele: mef(H)
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Clostridioides difficile
Sequence Accession: MW269960.1
Protein Accession: QQM99829.1
Notes: ARO:3007047