Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
macrolide efflux pump
Overview
Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.
The study found that treatment with slow-release clarithromycin led to increased macrolide resistance in oropharyngeal flora, with significant rises in ermB and ermC genes in streptococci and staphylococci, respectively.
Simultaneous detection of nine antibiotic resistance-related genes in Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization assay.
The study developed a multiplex PCR and reverse line blot hybridization assay to detect nine antibiotic resistance-related genes in Streptococcus agalactiae, including erm(B), erm(A/TR), mef(A/E), tet(M), tet(O), aphA-3, aad-6, int-Tn, and mreA. These genes were found to be associated with resistance to macrolides, lincosamides, streptogramin B, tetracyclines, and aminoglycosides.
Efflux-mediated drug resistance in bacteria: an update.
The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.
Genetic resistance elements carrying mef subclasses other than mef (A) in Streptococcus pyogenes
The study identifies various mef subclasses (mef(E), mef(I), mef(A/E), and a novel mef) associated with resistance genes (tet(M), tet(O), and catQ) in Streptococcus pyogenes, highlighting the diversity of genetic elements involved in macrolide and tetracycline resistance.
The fitness cost of antibiotic resistance in Streptococcus pneumoniae: insight from the field.
The study identified mefA/E and ermB as the primary mechanisms of azithromycin resistance in Streptococcus pneumoniae and estimated their relative fitness costs.
The application of multiplex PCR to detect seven different DNA targets in group B streptococci.
The study developed a multiplex PCR method to detect seven DNA targets in Group B Streptococcus (GBS), including the macrolide resistance genes ermB and mefA/E.
Antimicrobial activity, antibiotic susceptibility and virulence factors of Lactic Acid Bacteria of aquatic origin intended for use as probiotics in aquaculture.
The study identified the erythromycin resistance gene mef(A/E) in Pediococcus pentosaceus and Weissella cibaria, and the lincosamide resistance gene lnu(A) in Pediococcus pentosaceus.
Nasopharyngeal carriage, serotype distribution and antimicrobial resistance of Streptococcus pneumoniae among children from Brazil before the introduction of the 10-valent conjugate vaccine.
The study identified erythromycin resistance genes mef(A/E) and erm(B) in Streptococcus pneumoniae isolates, with the former being associated with the M phenotype. Penicillin non-susceptibility was linked to specific serotypes such as 14 and 23F.
Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Paraná, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants.
The study identified resistance to erythromycin and clindamycin in Streptococcus agalactiae isolates, primarily mediated by the ermA, ermB, and mefA/E genes.
In vitro activity of solithromycin against erythromycin-resistant Streptococcus agalactiae.
Solithromycin showed potent activity against erythromycin-resistant Streptococcus agalactiae, with MIC 50 and MIC 90 values of 0.03 μg/ml and 0.125 μg/ml, respectively. The study identified erm(B) and mef(A/E) as the primary resistance mechanisms.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
High Prevalence of Macrolide-resistance and Molecular Characterization of Streptococcus pyogenes Isolates Circulating in China from 2009 to 2016.
The study identified high prevalence of macrolide resistance in Streptococcus pyogenes isolates in China, with erm(B) and mef(A/E) genes being the primary mechanisms. Tet(M) was the main determinant of tetracycline resistance, and mutations in gyrA and parC were associated with fluoroquinolone resistance.
Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China.
The study characterizes the AMR genes and mutations in Streptococcus gallolyticus subsp. pasteurianus isolates from China, identifying erm(B), erm(A), erm(T), mef(A/E), tet(L), tet(O), and tet(M) as major contributors to erythromycin, clindamycin, and tetracycline resistance.
Prevalence of Various Vaccine Candidate Proteins in Clinical Isolates of Streptococcus pneumoniae: Characterization of the Novel Pht Fusion Proteins PhtA/B and PhtA/D.
The study identified the prevalence of various vaccine candidate proteins in clinical isolates of Streptococcus pneumoniae, including the novel Pht fusion proteins PhtA/B and PhtA/D. It also characterized resistance mechanisms such as erm(B), mef(A/E), tet(M), and mutations in pbp1a, pbp2x, and pbp2b contributing to macrolide, tetracycline, and penicillin resistance.
Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.
The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.
Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumoniae isolated from clinical samples in Tehran, Iran.
The study identified the presence of ermB, mefA/E, and tetM genes in invasive Streptococcus pneumoniae isolates, which contribute to resistance against erythromycin and tetracycline.
Molecular Characteristic, Antibiotic Resistance, and Detection of Highly Immunoreactive Proteins of Group B Streptococcus Strains Isolated From Urinary Tract Infections in Polish Adults.
The study identified ermB and mefA/E genes as contributors to macrolide resistance in Group B Streptococcus (GBS) strains isolated from urinary tract infections in Polish adults. The ermB gene was present in all cMLS B phenotype strains, while mefA/E was found in three M phenotype strains.
Increase of Macrolide-Resistance in Streptococcus pneumoniae Strains After the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Lima, Peru.
The study found a significant increase in macrolide resistance in Streptococcus pneumoniae strains after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in Lima, Peru. The primary resistance mechanisms identified were the erm(B) gene and the mef(A/E) gene.
Genetic diversity and antimicrobial resistance of invasive, noninvasive and colonizing group B Streptococcus isolates in southern Brazil.
The study identified the presence of macrolide resistance genes mef A/E, erm B, and erm A/TR in Group B Streptococcus (GBS) isolates, with serotype V being strongly associated with erythromycin resistance. The most common genotypes were Ia/MT12 and V/MT18, showing high resistance to macrolides.
Antibiotic resistance genes and molecular typing of Streptococcus agalactiae isolated from pregnant women.
The study identified several antibiotic resistance genes in Streptococcus agalactiae isolates from pregnant women, including ermB, mefA/E, ermTR, tetM, tetO, and aphA3, which confer resistance to macrolides, tetracyclines, and aminoglycosides.
Prevalence of macrolide-lincosamide-streptogramin resistant lactic acid bacteria isolated from food samples.
The study identifies the presence of MLS resistance genes ermB, mefA/E, msrA/B, and msrC in lactic acid bacteria isolated from food samples, highlighting the prevalence of macrolide-lincosamide-streptogramin resistance in LAB.
Baseline azithromycin resistance in the gut microbiota of preterm born infants.
The study identifies the presence of macrolide resistance genes in the gut microbiota of preterm infants, with erm(C) and msr(A) being the most common. These genes were found in various bacterial genera, including Staphylococcus and Enterococcus.
Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022.
The study identified the prevalence of antimicrobial resistance genes in Streptococcus suis isolates from Spain, including tet(O), erm(B), lnu(B), lsa(E), tet(M), and mef(A/E). High resistance levels were observed for clindamycin, chlortetracycline, and sulfadimethoxine.
The gut microbiota of wild birds undergoing rehabilitation as a reservoir of multidrug-resistant enterococci in a metropolitan area in Brazil.
The study identified multiple antimicrobial resistance genes in enterococci isolated from wild birds, including genes conferring resistance to aminoglycosides, erythromycin, tetracycline, and streptogramins.
Efflux-Mediated Macrolide Resistance in Clinical Streptococcus Isolates: A Comparative Molecular Study.
The study identified mef(A/E) as the dominant efflux-mediated macrolide resistance gene in UAE Streptococcus isolates, with functional validation of its efflux activity. msr(D) was also detected but at a lower frequency. No tet(K) was found.
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